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Database: UniProt
Entry: H3A6Y9_LATCH
LinkDB: H3A6Y9_LATCH
Original site: H3A6Y9_LATCH 
ID   H3A6Y9_LATCH            Unreviewed;       120 AA.
AC   H3A6Y9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   11-DEC-2019, entry version 38.
DE   RecName: Full=Glycoprotein hormones alpha chain {ECO:0000256|RuleBase:RU362129};
GN   Name=CGA {ECO:0000313|Ensembl:ENSLACP00000005410};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005410, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000005410}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000005410};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSLACP00000005410}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC       {ECO:0000256|RuleBase:RU362129}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362129,
CC       ECO:0000256|SAAS:SAAS00135156}.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha family.
CC       {ECO:0000256|RuleBase:RU362129, ECO:0000256|SAAS:SAAS00594029}.
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DR   EMBL; AFYH01204608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01204609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01204610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7897.ENSLACP00000005410; -.
DR   Ensembl; ENSLACT00000005458; ENSLACP00000005410; ENSLACG00000004814.
DR   eggNOG; ENOG410IWI0; Eukaryota.
DR   eggNOG; ENOG4111Q75; LUCA.
DR   GeneTree; ENSGT00390000012242; -.
DR   InParanoid; H3A6Y9; -.
DR   OMA; STCYHHK; -.
DR   TreeFam; TF332733; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR000476; Glyco_hormone.
DR   PANTHER; PTHR11509; PTHR11509; 1.
DR   Pfam; PF00236; Hormone_6; 1.
DR   PRINTS; PR00274; GLYCOHORMONE.
DR   SMART; SM00067; GHA; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00779; GLYCO_HORMONE_ALPHA_1; 1.
DR   PROSITE; PS00780; GLYCO_HORMONE_ALPHA_2; 1.
DR   PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00487241};
KW   Glycoprotein {ECO:0000256|RuleBase:RU362129};
KW   Hormone {ECO:0000256|RuleBase:RU362129, ECO:0000256|SAAS:SAAS00135161};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Secreted {ECO:0000256|RuleBase:RU362129, ECO:0000256|SAAS:SAAS00487242};
KW   Signal {ECO:0000256|RuleBase:RU362129}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|RuleBase:RU362129"
FT   CHAIN           25..120
FT                   /note="Glycoprotein hormones alpha chain"
FT                   /evidence="ECO:0000256|RuleBase:RU362129"
FT                   /id="PRO_5005398571"
SQ   SEQUENCE   120 AA;  13430 MW;  A1608AE69650C9FF CRC64;
     MAHKAKCIVG ILVILSVVMH VLHSFPDGEL MMQGCPECKL KESRYFSKPA APIYQCTGCC
     FSRAYPTPLR SKKTMSVPKN ITSEATCCVA KSFTRVTLMD NLKIENHTEC HCSTCYHHKS
//
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