ID H3A740_LATCH Unreviewed; 428 AA.
AC H3A740;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Pannexin {ECO:0000256|RuleBase:RU010713};
GN Name=PANX1 {ECO:0000313|Ensembl:ENSLACP00000005461.2};
GN Synonyms=PANX {ECO:0000256|RuleBase:RU010713};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005461.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005461.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Structural component of the gap junctions and the
CC hemichannels. {ECO:0000256|RuleBase:RU010713}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- PTM: S-nitrosylation inhibits channel currents and ATP release.
CC {ECO:0000256|PIRSR:PIRSR600990-50}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01224109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01224110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01224111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01224112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01224113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01224114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01224115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01224116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01224117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01224118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006010940.1; XM_006010878.2.
DR AlphaFoldDB; H3A740; -.
DR STRING; 7897.ENSLACP00000005461; -.
DR GlyCosmos; H3A740; 2 sites, No reported glycans.
DR Ensembl; ENSLACT00000005509.2; ENSLACP00000005461.2; ENSLACG00000004858.2.
DR GeneID; 102356176; -.
DR KEGG; lcm:102356176; -.
DR CTD; 393890; -.
DR eggNOG; ENOG502QT58; Eukaryota.
DR GeneTree; ENSGT00940000153972; -.
DR HOGENOM; CLU_050054_1_0_1; -.
DR InParanoid; H3A740; -.
DR OMA; IPDRFQC; -.
DR OrthoDB; 2996841at2759; -.
DR TreeFam; TF333142; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000004858; Expressed in pectoral fin and 4 other cell types or tissues.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR GO; GO:0006812; P:monoatomic cation transport; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0032732; P:positive regulation of interleukin-1 production; IEA:InterPro.
DR InterPro; IPR000990; Innexin.
DR InterPro; IPR039099; Pannexin.
DR PANTHER; PTHR15759; PANNEXIN; 1.
DR PANTHER; PTHR15759:SF5; PANNEXIN-1; 1.
DR Pfam; PF00876; Innexin; 1.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|RuleBase:RU010713};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Glycoprotein {ECO:0000256|PIRSR:PIRSR600990-51};
KW Ion channel {ECO:0000256|RuleBase:RU010713};
KW Ion transport {ECO:0000256|RuleBase:RU010713};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW S-nitrosylation {ECO:0000256|PIRSR:PIRSR600990-50};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00351};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT TRANSMEM 32..55
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 108..127
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 209..234
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 274..296
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT REGION 390..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 40
FT /note="S-nitrosocysteine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600990-50"
FT MOD_RES 346
FT /note="S-nitrosocysteine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600990-50"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600990-52"
FT CARBOHYD 254
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600990-51"
SQ SEQUENCE 428 AA; 48413 MW; 7A87DDA1A155CDF5 CRC64;
MAIAHVATEY VFSDFMLKDS SDSRYKGLRV ELAVDMIVTC VSVGLPLLLI SLAFAQEVSV
GTQISCFSPT NFSWRQAQYV DAFCWAAVQQ QTTIHSDTGR IPLWLHKFFP YILLLLAILL
YAPALFWRFT AAPHLYSDLK FIMEELDKAY NRAIKIAQSI VSGSKEGTSP TPEEIESLKQ
STWDIPDGCF KYPIVEQYLK TKKKSNHLII KYVICRIMSF VIILLACVYL GYYISLASLT
DEFSCNIRTG ILENDTSVPE KLQCKLIAVG IFQLLSYINL IVFVLLLPVI MYTMLVPLRQ
RTYFLRVYEI LPTLDYLDIS TRNYNDLSLY LLFLEENLSE LKSYKCLKVI ELIMDSGEGG
YDSLFLLTNF GQIRTDVVDG KSAYKMAAMK SKAEPDNKVP EDGASGDGAK ASKDGEPLRQ
RLVDSLNC
//