ID H3A766_LATCH Unreviewed; 732 AA.
AC H3A766;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=EPHA10 {ECO:0000313|Ensembl:ENSLACP00000005487.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005487.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005487.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AFYH01015072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01015073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01015074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01015075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01015076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01015077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01015078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01015079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01015080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01015081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A766; -.
DR STRING; 7897.ENSLACP00000005487; -.
DR Ensembl; ENSLACT00000005535.1; ENSLACP00000005487.1; ENSLACG00000004881.1.
DR eggNOG; KOG0196; Eukaryota.
DR GeneTree; ENSGT00940000155503; -.
DR HOGENOM; CLU_000288_141_4_1; -.
DR InParanoid; H3A766; -.
DR OMA; AXELSEY; -.
DR TreeFam; TF314013; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00063; FN3; 2.
DR CDD; cd05065; PTKc_EphR_B; 1.
DR CDD; cd09552; SAM_EPH-B2; 1.
DR CDD; cd12087; TM_EGFR-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF11; EPHRIN TYPE-B RECEPTOR 2; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 288..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..179
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 180..275
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 367..630
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 659..723
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT BINDING 399
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 732 AA; 81827 MW; A8B2F6C55CD6BE1E CRC64;
CRAVLPAGEN AIKAQACPSG SFKPLQGHEN CIHCPINSRT TSEGATSCVC RTGYYRADSD
PLEMPCTTIP SSPQNVISSV NETSLMLEWT SSRDTGGRED VVFNIICKSC STGRGLCTRC
GDNVQFVPRQ LGLTEPRVYI SDLLAHTQYT FEIQAVNGVS DQSPYSPQFA SVNITTNQAA
PSAVSIMHQV SRTVDSITLS WSQPDQPNGV ILDYELQYYE KELSEYNSSM VKSLTNTATI
RNLKPGTIYV FQVRARTVAG FGRYSGKMYF QTMTEAEYHT SIQEKLPLII GSAAAGLVFL
VAVVVIIIFL LRRRGFERTD SEYTDKLQHY TSGHVTPGMK IYIDPFTYED PNEAVREFAK
EIDISCVKIE QVIGAGEFGE VCSGNLKLPS KREIFVAIKT LKSGYTEKQR RDFLSEASIM
GQFDHPNVIH LEGVVTKSSP VMIITEFMEN GSLDSFLRQN DGQFTVIQLV GMLRGIAAGM
KYLSDMNYVH RDLAARNILV NSNLVCKVSD FGLSRFLEDD TSDPTYTSAL GGKIPIRWTA
PEAIQYRKFT SASDVWSYGI VMWEVMSYGE RPYWDMTNQD VINAIEQDYR LPPPMDCPSA
LHQLMLDCWQ KDRNSRPKFG QIVNNLDKMI RNPNSLKAMA PLSSGVNLPL LDRTVPDYSS
FSTIDEWLDA IKMGQYKEKF ESAGFNSFDV VSQMTMEDIL RVGVTLAGHQ KKILNSIQIM
RAQMNQIQSV EV
//
