ID H3A792_LATCH Unreviewed; 297 AA.
AC H3A792;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=ER membrane protein complex subunit 2 {ECO:0000256|RuleBase:RU367091};
GN Name=EMC2 {ECO:0000313|Ensembl:ENSLACP00000005513.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005513.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005513.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC (EMC) that enables the energy-independent insertion into endoplasmic
CC reticulum membranes of newly synthesized membrane proteins.
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU367091}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU367091}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SIMILARITY: Belongs to the EMC2 family. {ECO:0000256|ARBA:ARBA00010361,
CC ECO:0000256|RuleBase:RU367091}.
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DR EMBL; AFYH01200723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01200724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01200725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01200726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01200727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01200728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01200729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01200730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01200731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01200732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006008906.1; XM_006008844.1.
DR AlphaFoldDB; H3A792; -.
DR STRING; 7897.ENSLACP00000005513; -.
DR Ensembl; ENSLACT00000005561.1; ENSLACP00000005513.1; ENSLACG00000004901.1.
DR GeneID; 102356067; -.
DR KEGG; lcm:102356067; -.
DR CTD; 9694; -.
DR eggNOG; KOG3060; Eukaryota.
DR GeneTree; ENSGT00390000011922; -.
DR HOGENOM; CLU_052388_1_0_1; -.
DR InParanoid; H3A792; -.
DR OMA; MSDQEGW; -.
DR OrthoDB; 312673at2759; -.
DR TreeFam; TF312997; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000004901; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0072546; C:EMC complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR039856; EMC2-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12760:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR12760; TETRATRICOPEPTIDE REPEAT PROTEIN; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU367091};
KW Membrane {ECO:0000256|RuleBase:RU367091};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 155..188
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 297 AA; 34431 MW; D55BE64D9AE94B42 CRC64;
MASVSEMYDV TWEEMRDKLR KWREENYRNS EQIVCVGEEL INEHASKLGD DIWIIYEQVM
IAALDCSRDD LAWDCLHELR KQFPGSHRVK RLNGMICEAS ERYDEAIKEY DAILKEDSTN
TAARKRKIAI QKAQGNTVEA IRELNEYLEQ FVGDQEAWHE LSELYINEHD YAKAAFCLEE
LMMTNPHNHL YCQQYAEVKY TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA
AYSKASAKVK ENNLKYAAWA ANQINRAYQL AGRGKKDTKC SLKAVKDMLE ALQITQS
//