ID H3A8F0_LATCH Unreviewed; 434 AA.
AC H3A8F0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=TUB like protein 3 {ECO:0000313|Ensembl:ENSLACP00000005921.1};
GN Name=TULP3 {ECO:0000313|Ensembl:ENSLACP00000005921.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005921.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005921.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129}.
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DR EMBL; AFYH01135277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01135278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01135279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01135280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01135281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01135282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A8F0; -.
DR STRING; 7897.ENSLACP00000005921; -.
DR Ensembl; ENSLACT00000005973.1; ENSLACP00000005921.1; ENSLACG00000005256.1.
DR eggNOG; KOG2502; Eukaryota.
DR GeneTree; ENSGT00940000158155; -.
DR HOGENOM; CLU_028236_1_1_1; -.
DR InParanoid; H3A8F0; -.
DR OMA; PDIQEVM; -.
DR TreeFam; TF314076; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000005256; Expressed in pectoral fin and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0036333; P:hepatocyte homeostasis; IEA:Ensembl.
DR GO; GO:0061326; P:renal tubule development; IEA:Ensembl.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR InterPro; IPR005398; Tubby_N.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR PANTHER; PTHR16517:SF138; TUBBY-RELATED PROTEIN 3; 1.
DR Pfam; PF01167; Tub; 1.
DR Pfam; PF16322; Tub_N; 2.
DR PRINTS; PR01573; SUPERTUBBY.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR PROSITE; PS01200; TUB_1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 2..55
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 56..163
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 185..429
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 48806 MW; 172F6414E33D7C3B CRC64;
SQRALLEQKQ RKKRQEPLMV QPNPEARPRR SKVKRSEEQA PLVESQNSIC SDVIVDGIDG
PAAFLSSEVQ DLSTKIQFLS VGESTTDDSP EGGDDDTETL LEPASSKPDI QEILQERGIS
GSLKFDEEEA EDEESTRPRS PRLETSRPAS ATSHKSNTDI AASFAASPHT DSQLIDMNNL
EEFALQPALR GITMKCRVTR DKKGMDRGLY PTYFMHLERD DGKKVFLLAG RKRKKSKTSN
YLISVDPTDM SREGESFIGK VRSNLMGTKF TVYDNGLNPA KAQGLLEETN TRQELAAICY
ETNVLGFKGP RKMTVLIPGM SMTHERIPIR PQNENESLLT KWQNKQMENL IELHNKAPVW
NDDTQSYVLN FHGRVTQASV KNFQIVHEND PDYIVMQFGR VAEDVFTLDY NYPMCALQAF
SIGLSSFDSK LACE
//
