ID H3A8M7_LATCH Unreviewed; 378 AA.
AC H3A8M7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Interleukin 1 receptor type 2 {ECO:0000313|Ensembl:ENSLACP00000005998.1};
GN Name=IL1R2 {ECO:0000313|Ensembl:ENSLACP00000005998.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005998.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005998.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01136310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01136311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01136312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01136313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01136314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A8M7; -.
DR STRING; 7897.ENSLACP00000005998; -.
DR Ensembl; ENSLACT00000006050.1; ENSLACP00000005998.1; ENSLACG00000005325.1.
DR eggNOG; ENOG502QVTS; Eukaryota.
DR GeneTree; ENSGT01090000259985; -.
DR HOGENOM; CLU_051287_0_0_1; -.
DR InParanoid; H3A8M7; -.
DR OMA; LLWWTAN; -.
DR TreeFam; TF325519; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004910; F:interleukin-1, type II, blocking receptor activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR InterPro; IPR004077; IL-1_rcpt_II-typ.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF3; INTERLEUKIN-1 RECEPTOR TYPE 2; 1.
DR PRINTS; PR01539; INTRLEUKN1R2.
DR PRINTS; PR01536; INTRLKN1R12F.
DR SMART; SM00409; IG; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..378
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579684"
FT TRANSMEM 359..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..226
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 378 AA; 42598 MW; 6F879BF2F5E73A90 CRC64;
MFPFLIVVIS TCLTEVSAFR VQPMDITGRS GKCRGKIIQD KGFFVLKSEA AVLKCPSFAY
LEMDFSDATN HGFNLTWYKN DSGRVIPEGG SRIHTENDSL WFLPTTLEDS GYYVCVLRNV
SYCIEVGISL AIYDGESNHF NQLAYPQTIQ AFTTGKVVCP DVFSFLSRGS RLELKWYKGS
VPLSYSEGKF MSSTNYLLIQ DVSMGDGGYY TCEYTFTRDN TQHKVSRIIK VMIKDQVNNN
YAVIVSPTHY SIEAALGSQL IIPCKVFTGF GSDSFPLVMW LANNTLISDF FKDNRVREEQ
KRDIRENGAN YVEVELIFAE VRQEDFTTDF KCFANDYVGT ILGFPTRIPS VFKETSKLFA
WYIVVASVAL TCLIAAGI
//
