ID H3A922_LATCH Unreviewed; 911 AA.
AC H3A922;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
GN Name=LARS2 {ECO:0000313|Ensembl:ENSLACP00000006143.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000006143.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000006143.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-
CC tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA-
CC COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001372};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR EMBL; AFYH01098116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01098117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01098118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01098119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01098120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01098121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01098122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01098123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01098124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01098125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A922; -.
DR STRING; 7897.ENSLACP00000006143; -.
DR Ensembl; ENSLACT00000006195.1; ENSLACP00000006143.1; ENSLACG00000005448.1.
DR eggNOG; KOG0435; Eukaryota.
DR GeneTree; ENSGT00390000015114; -.
DR HOGENOM; CLU_004427_0_1_1; -.
DR InParanoid; H3A922; -.
DR OMA; TFMVLAP; -.
DR TreeFam; TF105662; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000005448; Expressed in chordate pharynx and 1 other cell type or tissue.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07958; Anticodon_Ia_Leu_BEm; 1.
DR CDD; cd00812; LeuRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR002302; Leu-tRNA-ligase.
DR InterPro; IPR025709; Leu_tRNA-synth_edit.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00396; leuS_bact; 1.
DR PANTHER; PTHR43740:SF3; LEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 3.
DR Pfam; PF13603; tRNA-synt_1_2; 1.
DR PRINTS; PR00985; TRNASYNTHLEU.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 72..259
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 271..432
FT /note="Leucyl-tRNA synthetase editing"
FT /evidence="ECO:0000259|Pfam:PF13603"
FT DOMAIN 434..603
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 643..683
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 748..865
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 911 AA; 103777 MW; 07DC0CE17AD704E7 CRC64;
MQSVLMRLES CSFCLKKRLS NWAGLLRRDG KLLVETRCTI YSETGRWEKD YRAETRKRVE
QWWQPKIKEQ SRCASETDKT KSKFYILSMF PYPSGKLHLG HVRVYTICDT IAHFQRMRGK
QVLNPMGWDA FGLPAENAAI ERGLDPEEWT KSNITHMRKQ LHSLSLCFDW EQEVTTCQPD
YYIWTQYLFI KLYEAGLAYQ KEALVNWDPV DQTVLADEQV DERGYSWRSG ARVEQKYLKQ
WFIKTTNYAK PLLDALADLP KWYGVKRMQA NWIGECTGCY FDFQLKVDGK DTGEKLSAYT
FKPEAVYGAS YLSILPSHRL LHGNSDLKKV LLKDFKSGRD SLTSLTAENL LTGQEIPVVI
SAKPEFEGYL DTKIALEGIP TVNIEDASVA KNLGLQCLEV IEALPDGTEK LINSGEFTGL
DRTEAFNAIT TQARNKRVGG YLTSSKLRDW LISRQRYWGT PIPIIHCQSC GTVPVPLEHL
PVLLPKVASF SGKGASPLTT TLDWLNCTCP KCKGPARRET DTMDTFVDSA WYYFRYTDPH
NTERPFDRGL ADHWMPVDLY IGGKEHAVMH LYYARFLGHF CSNQNMVKHR EPFYKLLVQG
LIKGQTFQLA GTGQYLKRDD VDFTGGSEPT HAGTKEKLEI TWEKMSKSKH NGMDPEEVVA
QYGIDTVRLY ILYAAPPEQD ILWDVKTDAI PGVLRWQARL WALVTKLISV RDAGTVPNPD
LLSIKEKAEA KKIWGNKNHA LTQHCKVTIH FTEDFLLNAA ISRLMGLSNT LSQASQRVIL
HSAEFEDGLA ALCIMVAPMA PHLASELWKG LSLVQNKLVS RYHWDDDVLL QVWPDVDPEY
LQQPDMVEIA VRINNKACGT VSMPQQVAKN AEKVRELVLQ SDLGIKHLKG YTIKKSFLSP
RTALINFLIE E
//
