ID H3A9J2_LATCH Unreviewed; 711 AA.
AC H3A9J2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=T cell activation RhoGTPase activating protein {ECO:0000313|Ensembl:ENSLACP00000006313.1};
GN Name=TAGAP {ECO:0000313|Ensembl:ENSLACP00000006313.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000006313.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000006313.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01226982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A9J2; -.
DR STRING; 7897.ENSLACP00000006313; -.
DR Ensembl; ENSLACT00000006366.1; ENSLACP00000006313.1; ENSLACG00000005602.1.
DR eggNOG; KOG4724; Eukaryota.
DR GeneTree; ENSGT00940000157993; -.
DR HOGENOM; CLU_014209_1_0_1; -.
DR InParanoid; H3A9J2; -.
DR OMA; NTKPEFN; -.
DR TreeFam; TF331062; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR PANTHER; PTHR23179:SF26; T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 109..297
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 327..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 711 AA; 80438 MW; AC46DAC95EAE7885 CRC64;
SREVKELWLD TLHWQIQTQD KDSEKVTSTA FLMKVLGGCK ASKTLTGSNM DYFIEARLEE
DAKRFSLTQF DCEDGSCHLI AEGNKRKKVI SWPFALRRNS DSRNLLFKQP LEDICEDNAL
PKPIIEILTI LFLKGPSTEG IFRKAANEKN RRKLRDLLNV GINIDLENES IHLLATVFKD
FLRELPQDVL CSELYDTWMT ALEKENIEER IKEIKQVVEK LPEYNLLLLR HFFCVLYHIS
KTSEVSKMDA SNLAICTAPN MLRPTGSTAH SIEVEKDRSE KVKTLVTFMI EYCCELFGED
VPALLGEAAE RLEHSDSTEL SLYQHSDSAY DSTDQDAESD SKDQMSPQLK ETESSSEHSS
SEFICSNESV KSCSSTTIFD KHTRKMDRRC SEPNILPSVG IPVGGINKQK LTRSHDNFVA
QQADQQMDKN LSGECFLKAL YRNKKAPMLK VNTCLHTELS TIPSTKASST SSLDSSYSNS
SECSVFTSSP LASPSSPKRS FFTRHLSFSA KSTEGGETGD NKTKRPSLSS SFKKNKKLLV
KANSLGAVPV ASRGSIKRKE NQASYDTLQE DYINETTQVQ LFPRHHSMSK DEVFQQVDQK
IPGKPPSYDE AIKSSCSVIT SNKKPITVQD LKKTLYLQDE KKATTDLWNT SPDSPFQTDL
EGTLPGRQQY YRQRAMSESV QKNGHEQLSH RWSQPFSEAY KQFPYAKESY V
//
