ID H3AAE1_LATCH Unreviewed; 3125 AA.
AC H3AAE1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Huntingtin {ECO:0000313|Ensembl:ENSLACP00000006612.1};
GN Name=HTT {ECO:0000313|Ensembl:ENSLACP00000006612.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000006612.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000006612.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in microtubule-mediated transport or vesicle
CC function. {ECO:0000256|ARBA:ARBA00002907}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the huntingtin family.
CC {ECO:0000256|ARBA:ARBA00007153}.
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DR EMBL; AFYH01090972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000006612; -.
DR Ensembl; ENSLACT00000006666.1; ENSLACP00000006612.1; ENSLACG00000005863.1.
DR eggNOG; ENOG502QR1D; Eukaryota.
DR GeneTree; ENSGT00390000015863; -.
DR HOGENOM; CLU_000428_0_0_1; -.
DR InParanoid; H3AAE1; -.
DR OMA; PNKMEEP; -.
DR TreeFam; TF323608; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000005863; Expressed in pelvic fin.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR048412; Htt_bridge.
DR InterPro; IPR048413; Htt_C-HEAT_rpt.
DR InterPro; IPR048411; Htt_N_HEAT_rpt-1.
DR InterPro; IPR000091; Huntingtin.
DR InterPro; IPR028426; Huntingtin_fam.
DR InterPro; IPR024613; Huntingtin_N_HEAT_rpt-2.
DR PANTHER; PTHR10170:SF10; HUNTINGTIN; 1.
DR PANTHER; PTHR10170; HUNTINGTON DISEASE PROTEIN; 1.
DR Pfam; PF20925; Htt_bridge; 1.
DR Pfam; PF20927; Htt_C-HEAT; 1.
DR Pfam; PF12372; Htt_N-HEAT; 1.
DR Pfam; PF20926; Htt_N-HEAT_1; 1.
DR PRINTS; PR00375; HUNTINGTIN.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT REGION 18..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2610..2639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3125 AA; 347677 MW; 27DC9C80DA97BE19 CRC64;
MATMEKLMKA FESLKSFQQQ QGPAIAEEPA QKQKKDPTTT KKDRLTHCLT ICENIVVQSL
RNSPEFQKLL GIAMELFLLC SDDSESDVRM VADECLNKVV KALMDSNLPR LQLELYKEIK
KSMGSQDLNE VVLRSIRLCW MVCPPQARPY LVNLLPCLTR ISKRPEEAVQ ETLAAAIPKI
MAALGNFAND SEIKVLLKAF VANLKSSSPT IRRTAAGSAV SICQHSRRTQ YFYTWLLNVL
LGLLVPVEDD RPNPLVLGVL LTLRYLMPLL QQQVKDTSLK GSFGVTRKET EISPSPMQLI
QVYELTLHYT QHRDHNVVTA ALELLQQLFR TPPPDLLHAL TTSGTMRSIS ITKSEADSRN
RSGSILELIA GGGSSCSPVL LRKQKGKVLS GEEEALEDES ETRSDVTTTT FTASVNSEAA
SDVPSSSGAS TGGSVSPVPE SVGHDIITEQ PRSQHNLQST DSVDLSGSDL TSTATDGDDD
EMLSRSSSQI STVQSDAAPD INGKITQDSS PTSDSSQTTT EGPDSAVTPS DSSELVLDGT
ESQYSGMQIG QLQDEEEETT NIVAEEFVET FKNSALAMNK PHLLQTMGHS RQSSDSSVDR
FISKDEGAEI GDLESKPSKI KGDIGHYTDD DAAPLIHCVR LLSASFLLTG QKNGLIQDKE
VRVSVKALAV SCVGAATALH PEAFFNKLYK IPWESTDKPE EQYVSDVLKY IEHGDPQIRG
ATAILCGTII HSILSKSRFN VESWMSSVKS STENTITLVD FIPLLQKTLK DESSVTCKLA
CAAVRHCITS LCSSSYSELG LQLLIDLLTL RNNSYWLVRT ELLETLAEMD FRLVSFLERQ
AENLHRGDHH YTGLLKLQER VLSDVVIFLL GDEDPRVRHV AATVLPRLVP RLFYDCDQGQ
ADPVIAVARE QSSVYLQLLM HETQPASHIT VSTITRTYRG YNILQNIPDV TVENSLSRVI
TAVSHALTSS TSRALTLGCV EALCLLSTIF PVCSWSVGWH CGYIASGSQA SRVHLYKNRG
RSFSMSQSNP TDESRKSCVV GMANMIQSLL SSAWFPLDLS SHQDALILAG NLLSAAAPKC
LKNPWTAEDD VNTSTNKPEE PWPALGDRTL VSMVEQLFSH LLKVINICAH IIDDVAPGPT
LKATLPSLAN PPSLSPIRRK GKEREPVEQT AAPMSPKKNS ETNPVARPAE SVGAAPTSKS
TSLGGFYHLP SYLKLYDVLK ATHANYKVTL DLQNSNEKFG SFLRSALDVL SQLLELATLH
DIGKCVEEIL GYLKSCFSRE ATMATVCVQQ LLKTLFGTNL ASQYDGFSSN PSRSLGKAQR
LGSSSLRPGL YHYCFMAPYT HFTQALADAS LRNMVQAEHE QDTSGWFDVL QKVSSQLKSG
IVNVTKHRAD KNAIHNHIRL FEPLVIKALK QYTTTTSVQL QRQVLDLLAQ LVQLRVNYCL
LDSDQVFIGF VLKQFEYIEV GQFRESEAII PSIFFFLVLL SYERYHSKQI IGIPKIIQLC
DGIMASGRKA VTHAIPALQP IVHDLFVLRG SNKADAGKEL ETQKEVVVSM LLRLIQYHQV
LEMFILVLQQ CHKENEDKWK RLSRQIADVI LPMLAKQQMH LDSHEALGVL NSLFETVAPS
SLRPVDMLLR SMFVIPSTLA LVGTVQLWIS GILAILRVLI SQSTEDIVLS RIQELSLSPN
LILCQNINRL KEGGECVPPV EEQNGETQVK YLPEETLARF LLQLVGILLE EVATKQIKVD
MSEQQHTFYC QQLGTLLMCV IHIFKSGMFR RITAAATKLF KGDGADGSFY TLENLNSLVQ
SMIPTYPSLV LLWCQILLLI NYTNYTWWSE VHQTPRRHSL SSTKLLSPQI SGDSDESESK
SKLGMCNREI VRRGALILFC DYVCQNLHDS EHLTWLIVNH VQDLIGLSHE PPVQDFISAV
HRNSAASGLF IQAIQSRCEN LTTPTMLKKT LQCLEGIHLS QSGAVLMLYV DKLICTPFRV
LARMVDTLVC RRVEMLLAET FQNSIAQLPV EELDRIQQYL HSNGLAQRHQ RLYSLLDRFR
AMIAEDTVSP SPLVSSHPLD GEKPLESIIV DKWGGKEFYL SLVQSQCCCR ADSALLECTK
LLNKLPQPEL YSIMTTKEFN LSLLAPCLSF GLHSMSGEQG SALFETACKV TLDHVTHSLQ
HLPGSHQVFQ PLKPMGNVSY WNKLSDLFGD GLYYQTIVTL CRALAQYLTS LSKQPADVHI
PVDKEADITR FIVLSLEALS WHLMNDQVPL SVDLQAALDC CCLALQQPGI WSLLASAAYV
TQACTVIICI KFIVEAGNST QVRYTKYIES TALFFEESVA EDCIAKAEPE YITIACEVMA
EMVESLQSVL CFGHRRNNSI PAFLTPILRN ITISLARLPL VNSYTRLPPL VWKLGWSPRA
GGDFGTSLPE IPVEFLQEKD IFREFIYRIN TLGWTNRTQF EETWATLLGV LVTQPIVMDQ
EEERPLEEDT ERTQINVLAV QAITSLVLSA MTLPVAGNPA VSCLEQQPRN KTLKALDTRF
GRKLSVIRGI VEREIQAMVS KRENIATHYP YQAWDPVPSL SPATSGNLVS HEKLLLQINM
EREMGSMEYK LGQVSIHSVW LGNSITPLRE EEWDEDEEDE SDVPAPSSPQ TSPINSRKHR
AGVDIHSCSQ FLLELYSQWI LPSNPGKKSP AILISEVVRS LLAVSDLFTE RNQFEMMYTT
LTELQKFHPS EDEILNQYLV PAICKAAAVL GMDKAIAEPV SRLLETTLRS THMPSRIGAL
HGILYVLECD LLDDTAKQLI PIISDYLVSN LRGIAHCVNV HNQQHVLVMC AAAFYLIENY
PLDVGPEFTA GIIQMCGVMV SGSEESTPSI IYHCVLRGLE RLLLSEQLSR LDGEALVKLS
VDRLNMHSPH RAMAALGLML TCMYTEKYVK KGKEKSSPGR ISNADPTAPD SESVIVAMER
VSVLFDRIRK GFPCEARVVA RILPQFLDDF FPPQDVMNKV IGEFLSNQQP YPQFMANVVY
KVFQTLHTTG QSSMVRDWVM LSLSNFTQRT PVAMAMWSLS CFFVSASTSP WVSALLPHVI
SRMGKSEQVD VNLFCLVAID FYRHQIDEEL DRRSFQSVFE IVASPGTPYH RLLTCLQSLH
QITQL
//
