ID H3AAM1_LATCH Unreviewed; 471 AA.
AC H3AAM1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Forkhead box C1 {ECO:0000313|Ensembl:ENSLACP00000006692.1};
GN Name=FOXC1 {ECO:0000313|Ensembl:ENSLACP00000006692.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000006692.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000006692.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; AFYH01117917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014347010.1; XM_014491524.1.
DR AlphaFoldDB; H3AAM1; -.
DR STRING; 7897.ENSLACP00000006692; -.
DR Ensembl; ENSLACT00000006746.1; ENSLACP00000006692.1; ENSLACG00000005935.1.
DR GeneID; 102360412; -.
DR KEGG; lcm:102360412; -.
DR CTD; 2296; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162303; -.
DR HOGENOM; CLU_035722_3_1_1; -.
DR InParanoid; H3AAM1; -.
DR OMA; TSWYLNQ; -.
DR OrthoDB; 5385885at2759; -.
DR TreeFam; TF316127; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000005935; Expressed in pectoral fin and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd20044; FH_FOXC1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR047391; FOXC1/C2-like_FH.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF401; FORKHEAD BOX C1-A-RELATED; 1.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 71..165
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 71..165
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 167..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 52098 MW; 38C1CD9B3E2DA72B CRC64;
MQARYPVSSP NSLGVVPYLS SDQSYYRAAG GGYAGMPTPM SMYPHHDQYQ ASMARAYGPY
TPQPQPKDMV KPPYSYIALI TMAIQNAPDK KITLNGIYQF IMERFPFYRD NKQGWQNSIR
HNLSLNECFV KVPRDDKKPG KGSYWTLDPD SYNMFENGSF LRRRRRFKKK DAVKDREDRE
RQLKDQSRQQ SQDTEQTATS QPVRIQDIKT ENGTSSPPQA VSPALNAVPK IESPDSSSSM
SSGSPHSIPS NRSIGLENTE HHHHSQSSAQ GFSVDNIMTS LRGSPQSASE LSSTMIASSR
TGITPSLSLS YSPSQTSLYS SPCSQNANST SATGAGIYHC NMQAMSLYAG DRSSHLTTTT
VDETLPDYSI TTTTSSLNHG SLNSSQDGHH PHQGRLASWY LNQTGDLGHL SSATYPGQQQ
NFHSVREMFE SQRIGLNNSP VNGNSSCQMA FPSSQSIYRT SGTFVYDCSK F
//
