ID H3AAR4_LATCH Unreviewed; 929 AA.
AC H3AAR4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=GTPase activating Rap/RanGAP domain like 3 {ECO:0000313|Ensembl:ENSLACP00000006735.1};
GN Name=GARNL3 {ECO:0000313|Ensembl:ENSLACP00000006735.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000006735.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000006735.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01158164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01158165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01158166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01158167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01158168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01158169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01158170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AAR4; -.
DR STRING; 7897.ENSLACP00000006735; -.
DR Ensembl; ENSLACT00000006789.1; ENSLACP00000006735.1; ENSLACG00000005974.1.
DR eggNOG; KOG3686; Eukaryota.
DR GeneTree; ENSGT00940000159362; -.
DR HOGENOM; CLU_008685_1_0_1; -.
DR InParanoid; H3AAR4; -.
DR OMA; FEGYSER; -.
DR TreeFam; TF318626; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711:SF62; GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00036; CNH; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 118..334
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 416..727
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 738..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 929 AA; 105068 MW; EB45CCB3E2535713 CRC64;
NTDYTPGTWR RTDVHLENPE YHTRWYFKYF LGKVHQNYVG TDAEKNPFFL SVVLSDQNNQ
RVPQYRAILW RKTGSQKICL PYSPTKTLSV KSILSAMNLD KFEKGPREIL NPEIQKDLLV
LEEQEGSVNF KFGVLYAKDG QLTDDEMFSN ETGSEGFQKL LNLLGDTITL KGWAGYRGGL
DTRNDTTGIH SIYTVYQGHE IMFHVSTMLP YSKENKQQVE RKRHIGNDIV TIVFQEGEES
SSSFKPSMIR SHFTHIFALV RYNKQNDSYR LKIFSEESVP LFGPPLPSPP VFTDHHEFRD
FMLVKLINGE KATLETPTFA QKRQRTLDML IRSLYQDLMP DLHKNMLNRR SFSDVLPESP
KSARKKEEAR QAEFVRVGQA LKLKTIVRGD APTSLATTGV CRKEPWESQC FSSNFPYEAA
CSDSWGQSLL ISTDAGVLLL DEGQTPVPVF DKTLPVKQMH VLEAQDLLIT RADKGKDARL
FVFRLNAIKK GLKEKQLVKT KYDCRENKLE KTKGCHLYAI NTHHSTELRI VVAIRNKLLL
ITRKLNRFDS LTSVSIVTSY SESPMEDFQY IREICLSDPP VVMTLVDGPT GENDNMICVA
YRHQFDLVNE STGEIYRLHH VETSRVNFVA AIDVYEDGEA GLLLCYNYIC YYKKVCPFNG
GSPVVHPSAS DFHFSWNQVP NAIVCAFPYI LAFTVDSIEI RLVVNGNLVH TAVVPELQLV
ASRSDIFFIS AAVNAASNNS SKDTSSHSSP QTPTAQEMPV LSTPLEDEAQ YKHLYKIPLS
NLVGRSIERP LKSPMIAKVI TTPTSCIVSA IPVAHSLSLS RMEIKEIASR TRKELLGLKA
DSCPNKTEGL QKNRKLSRKP VKREPHQGAV RSTSSDRILP GSFESEHEEQ RHYSTSSDPD
TTLNVEEGQP LTSPFQLTAS LDEDVVDLK
//
