ID H3AB22_LATCH Unreviewed; 908 AA.
AC H3AB22;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324};
DE EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324};
GN Name=HK3 {ECO:0000313|Ensembl:ENSLACP00000006843.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000006843.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000006843.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
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DR EMBL; AFYH01039447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01039448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01039449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AB22; -.
DR STRING; 7897.ENSLACP00000006843; -.
DR Ensembl; ENSLACT00000006901.1; ENSLACP00000006843.1; ENSLACG00000006074.1.
DR eggNOG; KOG1369; Eukaryota.
DR GeneTree; ENSGT00950000182787; -.
DR HOGENOM; CLU_014393_1_0_1; -.
DR InParanoid; H3AB22; -.
DR TreeFam; TF314238; -.
DR UniPathway; UPA00109; UER00180.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 2.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.367.20; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF1; HEXOKINASE-3; 1.
DR Pfam; PF00349; Hexokinase_1; 2.
DR Pfam; PF03727; Hexokinase_2; 2.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 4.
DR PROSITE; PS51748; HEXOKINASE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 23..215
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 221..456
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT DOMAIN 467..657
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 664..898
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 908 AA; 100567 MW; D43A5D5F44881F96 CRC64;
IFSGHNLTIY YTKVEKNGIA NIGKCLDSLY LSKEKLLQIS SLMLENMKKG LGKDTNPTAT
VKMLPTYVRA TPDRTEKGEF LALDLGGTNF RVLRVKVEEK NVEMESEIYA IPQEIMLGTG
TQLFDHIAQC LSQFLDKHYI IKKTLSLGFT FSFPCKQIDL QKSILISWTK GFCSGVEGED
VVLLLRDAIC NRGDYDIDVI AVVNDTVGTM ISYGYDDPKC EIGLIVGTGS SACYMEEICN
IDLIEGNEGR MCINMEWGAF GDDGVLSDIQ TEFDLEVDRL SLNPGKQTFE KMISGMYMGE
IVRLILVQLA NQHLLFNGIT TPALMTKGKF ETKNVSEIED NTCGLAKAKD ILCNLNLDPS
DQDCIIVKQI CSAVSTRSAN LCTAGLASIV NHIQETRGLD NLKTSVGVDG TVYKKHPKYL
RRLPQFLQQK LAPDCDVNFI LSEDGSGKGA ATVTAVAYQL AEQRCQIDET LVSFKLSSDQ
LVDIKQKMRA EMEKGLTKET YLNASVKMLP TFVRTIPDGS DKERGNYLVL ELGDTNFQVL
FVTIEGKESG AKIENKTYLI SEEVMHGRGE ELFDKIVDCI DEFLKLLLGF IFSFPCRLTG
LDKGILINWT KGFKASSCEG EDVVMLLQEA IDRRPDVHCD VVAIVNDTVG IMMACGYEEP
NCEVGLIVGT GSNACYMEEM KNIETVEGDE GRMCINMEWG AFRDDGCIDE FITQFDRIVD
ECSVNAGKQR YEKLMSGMYL GEIVRNILNF AEKGILFCGQ VSEQLKTKDV FETKFLSQIE
SDRLVLLQVR SILQDLGLDS NCDGRIIVKE ACHTVSQRAA QLCGAAVAAV VEKIRENRSL
DHLVSAVTVG VDGSLFKLHP HFSFAIKYTV KELAPQCDVS FLLSQNGAGK GVALITAMAC
KIRETGHL
//
