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Database: UniProt
Entry: H3AB78_LATCH
LinkDB: H3AB78_LATCH
Original site: H3AB78_LATCH 
ID   H3AB78_LATCH            Unreviewed;       880 AA.
AC   H3AB78;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   20-JUN-2018, entry version 38.
DE   SubName: Full=N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2b {ECO:0000313|Ensembl:ENSLACP00000006899};
GN   Name=NDST2 {ECO:0000313|Ensembl:ENSLACP00000006899};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000006899, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000006899}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000006899};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000006899}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AFYH01062517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01062518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01062519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01062520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01062521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01062522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01062523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01062524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01062525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01062526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_014343402.1; XM_014487916.1.
DR   STRING; 7897.ENSLACP00000006899; -.
DR   Ensembl; ENSLACT00000006958; ENSLACP00000006899; ENSLACG00000006124.
DR   GeneID; 102367227; -.
DR   CTD; 8509; -.
DR   eggNOG; KOG3703; Eukaryota.
DR   eggNOG; ENOG410XQN4; LUCA.
DR   GeneTree; ENSGT00760000119023; -.
DR   InParanoid; H3AB78; -.
DR   OMA; NYYRGLD; -.
DR   OrthoDB; EOG091G02CP; -.
DR   TreeFam; TF313193; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR021930; Heparan_SO4_deacetylase.
DR   InterPro; IPR037359; NST/OST.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR10605; PTHR10605; 1.
DR   Pfam; PF12062; HSNSD; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     20     38       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       26    510       HSNSD. {ECO:0000259|Pfam:PF12062}.
FT   DOMAIN      600    850       Sulfotransfer_1. {ECO:0000259|Pfam:
FT                                PF00685}.
SQ   SEQUENCE   880 AA;  101983 MW;  3E9A78EE3B126402 CRC64;
     MFNFWKLIRN IRQLELHRLI LLLMVFSLVS MCFLAYYVTN SPKIKEAPPL PFSDCNNQPR
     ISLPPQVYRR YIKSMDTSRT DSVVLVFVES IYSQLGQEIV AILESSRFKY RTEIAPGKGD
     MPTLTDKDRG HYALIIYENI LKYVNLDAWN RDLLDKYCVE YGAGIIGFFK ANENSLLSAQ
     LKGFPLFLHS NLGLRDYHIN PNAPLLYVTR ANEVEQGPLP GDDWTVFQSN HSTYEPVLLA
     STKSSESIPH LNTHKALHAT VVQDLGLHDG IQRVLFGNNL NFWLHKLIFV DAIAYLTGKR
     LCLPLDRYVL VDIDDIFVGK ERTRMKVSDV EALLNTQTKL RTLVPNFTFN LGFSGKFYHT
     GTEEEDEGDD MLLKHRNEFW WFPHMWSHMQ PHLFHNVTVL AEQMKLNKQF AVEHGIPTDM
     GYAVAPHHSG VYPIHTQLYE AWKSVWGIKV TSTEEYPHLR PARYRRGFIH NGIMILPRQT
     CGLFTHTIFY NEYPGGSKEL DKSIRGGELF LTVLLNPISI FMTHLSNYGN DRLGLYTFES
     LVKFVQCWTN LKLKTLPPVQ LAEKYFEIFP EEKNPLWQNP CDDKRHKDIW SKEKTCDRLP
     KFLIVGPQKT GTTALHLFLS MHPAITSNFP SSTTFEEIQF FNGLNYHKGI DWYMEFFPFP
     SNVSTDFMFE KSANYFDAEL VPKRTAALLP RAKILTVLVN PADRAYSWYQ HQRAHGDPVA
     LNYSFHQVIS AGSNSLQEVR NLQSRCLVPG WYSTHLERWL TYYQPSQILI VDGQQLRNDP
     VTVLETVQKF LGVTPHFNYT QALKFDENKG FWCQLLDGGK SKCLGKGKGR KYPEMDAASW
     TFLTEFYREH NIELSKLINR LRQPLPTWLR EELQHNTKWS
//
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