ID H3ACD0_LATCH Unreviewed; 294 AA.
AC H3ACD0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Secreted frizzled related protein 2 {ECO:0000313|Ensembl:ENSLACP00000007301.2};
GN Name=SFRP2 {ECO:0000313|Ensembl:ENSLACP00000007301.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007301.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000007301.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; AFYH01226216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006011139.1; XM_006011077.1.
DR AlphaFoldDB; H3ACD0; -.
DR STRING; 7897.ENSLACP00000007301; -.
DR MEROPS; I93.002; -.
DR Ensembl; ENSLACT00000007361.2; ENSLACP00000007301.2; ENSLACG00000006474.2.
DR GeneID; 102365376; -.
DR KEGG; lcm:102365376; -.
DR CTD; 6423; -.
DR eggNOG; KOG3577; Eukaryota.
DR GeneTree; ENSGT00940000156432; -.
DR HOGENOM; CLU_054647_0_0_1; -.
DR InParanoid; H3ACD0; -.
DR OMA; NFGQHDL; -.
DR OrthoDB; 4814466at2759; -.
DR TreeFam; TF350133; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000006474; Expressed in pelvic fin and 4 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd07446; CRD_SFRP2; 1.
DR CDD; cd03580; NTR_Sfrp1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR041764; SFRP2_CRD.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF45; SECRETED FRIZZLED-RELATED PROTEIN 2; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..294
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579809"
FT DOMAIN 34..154
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 171..294
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 49..95
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 86..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 117..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 294 AA; 33174 MW; F4C6B49265E54B4E CRC64;
MYNLYSLALV MLAASSCVKS VNGMYPFGQS EFSYKRSNCK PIPATLVLCH GIEYPNMRLP
NLLGHETMKE VLQQASSWIP LVQKQCHPDT KKFLCSLFAP VCIDDLDETI QPCRSLCEQV
KESCAPVMSA FGFPWPDMLE CSRFPPDNDL CIPPASTEHF VPATKTVPKV CDACKSKEDN
DNEIAENLCK NDFALKIKVK EISYINGDTK IIPETKSKTI YKLNGVTERD LKKTVLWLKD
GLQCTCDEMN DINAPYLVMG QKLGGNLVIT SVKRWQKGQK EFKRISRSIR KLQC
//
