ID H3ADA4_LATCH Unreviewed; 212 AA.
AC H3ADA4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=glutaminyl-peptide cyclotransferase {ECO:0000256|ARBA:ARBA00012012};
DE EC=2.3.2.5 {ECO:0000256|ARBA:ARBA00012012};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007625.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000007625.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-
CC [peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736,
CC Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722,
CC ChEBI:CHEBI:87215; EC=2.3.2.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000001};
CC -!- SIMILARITY: Belongs to the glutaminyl-peptide cyclotransferase family.
CC {ECO:0000256|ARBA:ARBA00006014}.
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DR EMBL; AFYH01034848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3ADA4; -.
DR STRING; 7897.ENSLACP00000007625; -.
DR Ensembl; ENSLACT00000007689.1; ENSLACP00000007625.1; ENSLACG00000006756.1.
DR eggNOG; KOG3946; Eukaryota.
DR GeneTree; ENSGT00390000003107; -.
DR HOGENOM; CLU_045003_3_0_1; -.
DR InParanoid; H3ADA4; -.
DR TreeFam; TF315071; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000006756; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0016603; F:glutaminyl-peptide cyclotransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.630.10; Zn peptidases; 2.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR040234; QC/QCL.
DR PANTHER; PTHR12283; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR PANTHER; PTHR12283:SF3; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-LIKE PROTEIN; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 94..200
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 212 AA; 24688 MW; 30BA7621DCB0BBF9 CRC64;
VRQLTSQVDI QRLWKAYLSP ILKERLPGTP GHQQVRQVGV FELKKVLISP PKKKKKKGKK
ELMTFTQSFY SLLESLPSQP NPLFLFYILL LQDMFVLLDL LGTPQPFIVN HFENTARWFN
RLVATEKRLH KLGLLQLHPV EQIYFHKEVS YGTVEDDHVP FLQKGVPVLH LISTPFPEVW
HTMEDTEENL HPPTIANLCK ILTIFLAEYL KL
//
