ID H3ADH2_LATCH Unreviewed; 752 AA.
AC H3ADH2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=STAT1 {ECO:0000313|Ensembl:ENSLACP00000007693.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007693.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000007693.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR EMBL; AFYH01211803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01211804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01211805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01211806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01211807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01211808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01211809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01211810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01211811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01211812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006009914.1; XM_006009852.2.
DR AlphaFoldDB; H3ADH2; -.
DR Ensembl; ENSLACT00000007757.2; ENSLACP00000007693.2; ENSLACG00000006815.2.
DR GeneID; 102353760; -.
DR CTD; 6772; -.
DR GeneTree; ENSGT01050000244905; -.
DR HOGENOM; CLU_014189_3_0_1; -.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000006815; Expressed in pelvic fin and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16851; STAT1_CCD; 1.
DR CDD; cd16845; STAT1_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 6.10.250.3310; signal transducer and activator of transcription 1; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR038295; STAT1_C_sf.
DR InterPro; IPR022752; STAT1_TAZ2-bd_C.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF18; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA_BETA; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12162; STAT1_TAZ2bind; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 574..680
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 139..166
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 752 AA; 87356 MW; 7AD15394D3CB7514 CRC64;
MSQWYQLQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEN QDWEHAAMND SFATLRFHDL
LSQLDDQYSR FNQENNFLLQ HNIRKSKRNL QDNFQEYPVQ MAMIINNCLR EERKILASAQ
MFEQNQVGNT QNTVMLDKQK EMDNKVKKVK NRVQEVEQDI KTLEDVQDEY DFKCKTLQSR
EHEPNGLKPN ELKQEQMVIR SMFITLDIKR KEVVGKMIDL LNVTEQTQDA LINDELVDWK
HRQQISCIGG PPNACLDQLQ NWFTIVAESL QQVRQQLKKL EELEQKFTYE PDPITQQKQF
LGERTHSLFK QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK LQELNYQLRV
KAQFDKDVNE KNTVKGFRKF NILGTNSKVM NMEESTNGSL AAEFRHLQLK EQKNAGSRTN
EGPLIVTEEL HSLCFDTQLC QPGLVIDLET TSLPLVVISN VSQLPSGWAS ILWYNMLTSE
PKNLSFFLNP PAARWSQLSE VLSWQFSSVT KRGLNADQLS MLEEKLLGPN NCSGDGLIPW
TKFCKENIGE KSFSFWLWIE GILELIKRHL LSLWNDGCIL GFVSKEKERA LLKDQRPGTF
LLRFSESSRD GAITFTWVER SQNEPHFHAV EPYTKKELTA VAFPDIIRNY KVMAAENIPE
NPLRYLYPEI PKDSAFGKYY ARSKEPSEPM DVDDPKGSGY IKTELISVSE VHPSRLQTTE
NLLPMSPEDF DEVTRIISPA EIDTVMCQAY ST
//
