ID H3ADV7_LATCH Unreviewed; 823 AA.
AC H3ADV7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|ARBA:ARBA00017947, ECO:0000256|PIRNR:PIRNR007949};
GN Name=VPS16 {ECO:0000313|Ensembl:ENSLACP00000007828.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007828.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000007828.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport and
CC autophagic pathways. Believed to act as a core component of the
CC putative HOPS and CORVET endosomal tethering complexes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Late endosome membrane {ECO:0000256|PIRNR:PIRNR007949}; Peripheral
CC membrane protein {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Lysosome membrane
CC {ECO:0000256|PIRNR:PIRNR007949}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Note=Cytoplasmic, peripheral membrane
CC protein associated with late endosomes/lysosomes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SIMILARITY: Belongs to the VPS16 family.
CC {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01219764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01219765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01219766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01219767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01219768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3ADV7; -.
DR STRING; 7897.ENSLACP00000007828; -.
DR Ensembl; ENSLACT00000007894.1; ENSLACP00000007828.1; ENSLACG00000006933.1.
DR eggNOG; KOG2280; Eukaryota.
DR GeneTree; ENSGT00390000003896; -.
DR HOGENOM; CLU_008909_0_0_1; -.
DR InParanoid; H3ADV7; -.
DR OMA; HMTIRDH; -.
DR TreeFam; TF105673; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000006933; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0033263; C:CORVET complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 2.
DR PIRSF; PIRSF007949; VPS16; 2.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|PIRNR:PIRNR007949};
KW Lysosome {ECO:0000256|PIRNR:PIRNR007949};
KW Membrane {ECO:0000256|PIRNR:PIRNR007949};
KW Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT DOMAIN 5..302
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 340..403
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 501..819
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
SQ SEQUENCE 823 AA; 94975 MW; A0C87C809215409C CRC64;
MAFVTANWNP LGNVFYRKID LYAMEWNMRE DFKDCLIAAA PYGGAIALLK EDSRRERSPS
SRPVLEIYSS SGFPMANFPW KSGQVVHIGW TLSEDLLCVQ DNGTVLIYDI FGSFKRHFSM
GSEVLQPRVI EAKVFHSPYG TGVAILTGAY KFTCATNIEE LKLRRLTEVP GLQNSPSCWA
VLAQERETKV ILATGKDLYI LDNTACTSVT LPGIGPQVNS YCEIAVSFNY KYLALFADSG
YIWMGLSSLQ EKMWEFDTKI RTPPKQMVWC IRPKCKQPSV VARWDKLLVV AGKQESIQYP
FMNPPYVFLM YLNYLNHAKL EMRQESSLFF HEGFFFFFFF KKESQKADEY LREIKDQNLL
LVAVQQCIEA AGYEHEPNTQ KTLLRAASFG KCFISDYPRD DFVNMCRDLR VLNAIHDYRI
GIPLSYPQYT KLTTEVLIDR LVLRRLYPLA IKICEYLKIS EFRGASRVLA HWACYKVQQK
DENDDEVARA INQKLGDTPG ISYSDIAARA YECGRMELAI KLLEYEPRSG EQVPLLLKMK
RSQLALNKAI ESGDTDLVYT IVTHLKNEMN RGDFFMTLQN QPVALSLYRQ FCKHQEQDTL
KDLYNQDDDH QELGNFYVRS SYSFEKTIEG RVATLHSAVD EYNKAKSEFA AKATEDQIKL
LRFQRRLQEE LDKPYLDLSL HDTIHNLILD NKHKQAEQLY KDFKVPDKRF WRLKISALAE
KEEWEELEKF SKSKKSPIGY MPFVEICLKY HSRYEAKKYV PKVSPEQKVK AYIMVGDLDQ
AAEAAIEHKN DSELNLVLSK CTSATQQSVV EKINKAKAQL LKK
//
