ID H3ADZ7_LATCH Unreviewed; 580 AA.
AC H3ADZ7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Endonuclease/exonuclease/phosphatase family domain-containing protein 1 {ECO:0000256|ARBA:ARBA00015260};
GN Name=EEPD1 {ECO:0000313|Ensembl:ENSLACP00000007868.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007868.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000007868.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01129403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01129404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01129405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01129406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01129407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01129408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01129409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01129410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01129411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01129412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006002410.1; XM_006002348.2.
DR RefSeq; XP_014347704.1; XM_014492218.1.
DR AlphaFoldDB; H3ADZ7; -.
DR STRING; 7897.ENSLACP00000007868; -.
DR Ensembl; ENSLACT00000007934.2; ENSLACP00000007868.2; ENSLACG00000006965.2.
DR GeneID; 102348160; -.
DR KEGG; lcm:102348160; -.
DR CTD; 80820; -.
DR eggNOG; KOG1857; Eukaryota.
DR GeneTree; ENSGT00390000009677; -.
DR HOGENOM; CLU_033721_1_0_1; -.
DR InParanoid; H3ADZ7; -.
DR OMA; HLVPANT; -.
DR OrthoDB; 3037349at2759; -.
DR TreeFam; TF328735; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000006965; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd10283; MnuA_DNase1-like; 1.
DR Gene3D; 1.10.150.280; AF1531-like domain; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 1.10.150.320; Photosystem II 12 kDa extrinsic protein; 1.
DR InterPro; IPR004509; Competence_ComEA_HhH.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR NCBIfam; TIGR00426; competence protein ComEA helix-hairpin-helix repeat region; 1.
DR PANTHER; PTHR21180; ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR21180:SF32; ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF12836; HHH_3; 2.
DR SMART; SM00278; HhH1; 4.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 49..68
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 79..98
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 156..175
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 186..205
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT REGION 103..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..135
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 64446 MW; B64F5AA195BC73BE CRC64;
MGGNLGCHRS IPRDPSDITG QKRKFSAACN FSNILVNQER LNINTATEEE LMTLPGVNRT
VAQSIVQYRQ CIGGFKKVED LALVSGVGAA KLEQIKVEIC VSNKSSSAGH SPSSLRRDHH
HHHHHHHHHL HHHPLHQDHQ QPCCSPKINL NTAGPAQLMT IRGLQEKVAN SIVGYRQEHG
PFKSVEDLLK VDGISPSLVD RLRLQVFAER SRPPSTHTNG GLHFTPCKPH PSPTSLSLQS
EDLDLPPGGP IQIISTRPAV ELFSGLRDGR LVLRLATWNL QHCSLEKANN PGVREVVCMT
LLENSIKLLA VQELADKDAL EKLCSELNQP TLPNVRKWKG SRGSWKCAVS EKPSGQLHKC
VEYAGFLWDT SSGIQLKESA LLENPQTNGN GKHTFPRPYI AHFKVGLNDI TLVNIHLNMP
TTAGENTGKN QNETQKLPVF TDTLQETLKG EKDLIILGDF SLAPDANDFD ILRKERFHPL
VPASTFTNIS TKNPQGFKSL DNIWVSRTLK KVCTGHWAVV REGLTNPWIP DNWSWGGVAS
SHCPILAEFY TEKDLNKKEP VRNGNRVTVE LTEANSKHER
//
