ID H3AE06_LATCH Unreviewed; 456 AA.
AC H3AE06;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=RNA-binding protein NOB1 {ECO:0000256|PIRNR:PIRNR037125};
GN Name=NOB1 {ECO:0000313|Ensembl:ENSLACP00000007877.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007877.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000007877.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in mRNA degradation.
CC {ECO:0000256|PIRNR:PIRNR037125}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR037125}.
CC -!- SIMILARITY: Belongs to the NOB1 family. {ECO:0000256|ARBA:ARBA00005858,
CC ECO:0000256|PIRNR:PIRNR037125}.
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DR EMBL; AFYH01175268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01175269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01175270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006006819.1; XM_006006757.2.
DR AlphaFoldDB; H3AE06; -.
DR STRING; 7897.ENSLACP00000007877; -.
DR Ensembl; ENSLACT00000007943.1; ENSLACP00000007877.1; ENSLACG00000006973.1.
DR GeneID; 102356150; -.
DR KEGG; lcm:102356150; -.
DR CTD; 28987; -.
DR eggNOG; KOG2463; Eukaryota.
DR GeneTree; ENSGT00390000015857; -.
DR InParanoid; H3AE06; -.
DR OMA; GYELECE; -.
DR OrthoDB; 5473723at2759; -.
DR TreeFam; TF105838; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000006973; Expressed in post-anal tail muscle and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IEA:InterPro.
DR CDD; cd09876; PIN_Nob1-like; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 6.20.210.10; Nin one binding (NOB1), Zn-ribbon-like; 1.
DR InterPro; IPR039907; NOB1.
DR InterPro; IPR017117; Nob1_euk.
DR InterPro; IPR036283; NOB1_Zf-like_sf.
DR InterPro; IPR014881; NOB1_Zn-bd.
DR InterPro; IPR033411; Ribonuclease_PIN.
DR InterPro; IPR033461; WRNPLPNID.
DR PANTHER; PTHR12814; RNA-BINDING PROTEIN NOB1; 1.
DR PANTHER; PTHR12814:SF2; RNA-BINDING PROTEIN NOB1; 1.
DR Pfam; PF08772; NOB1_Zn_bind; 1.
DR Pfam; PF17146; PIN_6; 1.
DR Pfam; PF15017; WRNPLPNID; 1.
DR PIRSF; PIRSF037125; D-site_20S_pre-rRNA_nuclease; 1.
DR SUPFAM; SSF144206; NOB1 zinc finger-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR037125}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037125};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR037125}.
FT DOMAIN 9..95
FT /note="Ribonuclease PIN"
FT /evidence="ECO:0000259|Pfam:PF17146"
FT DOMAIN 167..256
FT /note="Putative WW-binding"
FT /evidence="ECO:0000259|Pfam:PF15017"
FT DOMAIN 304..376
FT /note="Nin one binding (NOB1) Zn-ribbon-like"
FT /evidence="ECO:0000259|Pfam:PF08772"
FT REGION 138..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 314
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037125-1"
FT BINDING 317
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037125-1"
FT BINDING 329
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037125-1"
FT BINDING 332
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037125-1"
SQ SEQUENCE 456 AA; 51253 MW; FEC02B606E80805B CRC64;
MAMAVVEHVV ADAGAFLKNA PLKDIGKNIY TLKEVVREIR DKDTKRRLAV LPYQLCFKEP
FPEYIRLVTE FSKKTGDYPS LSATDIKVLA LTYQLEVENV GVDHLKKEPE TNVQVSTTLR
HPEAPVNIAG FYLPSKPKHH NEVHPEDKTA SEHLGVSDEM PASENPEYSS FWYWRNPLPS
IEADLQDILN AENAVVAKDA SSVFEKLQDL NLSSEHHLCR NSVEEQNNEK AGVTPLDENS
EEEEDEDDGG SWITPSNIKQ IQQDMGSHEA PVDIKVGCLT TDFAMQNVLI QIGLHVLSVN
GMLIRQARNY ILRCHACFKA TTNMTKVFCP NCGNKTLKKV AVTVDENGCV HMHFSRNPKV
LNSTGLRYSL PAPKGGKHAN NPHLVEDQRF PQQRLSKKAR QKTNVFDPDY IAGVSPFAEN
DTYSRSANLN VRDSHLGAGR RRMNPNVTMK KFVKRK
//
