ID H3AEE1_LATCH Unreviewed; 1017 AA.
AC H3AEE1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 {ECO:0000313|Ensembl:ENSLACP00000008012.2};
GN Name=SMARCA5 {ECO:0000313|Ensembl:ENSLACP00000008012.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008012.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000008012.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC {ECO:0000256|ARBA:ARBA00009687}.
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DR EMBL; AFYH01136125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01136126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01136127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01136128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01136129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01136130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006002943.1; XM_006002881.2.
DR AlphaFoldDB; H3AEE1; -.
DR STRING; 7897.ENSLACP00000008012; -.
DR Ensembl; ENSLACT00000008078.2; ENSLACP00000008012.2; ENSLACG00000007091.2.
DR GeneID; 102354964; -.
DR KEGG; lcm:102354964; -.
DR CTD; 8467; -.
DR eggNOG; KOG0385; Eukaryota.
DR GeneTree; ENSGT00940000156733; -.
DR HOGENOM; CLU_000315_0_3_1; -.
DR InParanoid; H3AEE1; -.
DR OMA; HLWENCG; -.
DR OrthoDB; 5482994at2759; -.
DR TreeFam; TF300674; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000007091; Expressed in pelvic fin and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR CDD; cd18064; DEXHc_SMARCA5; 1.
DR CDD; cd00167; SANT; 2.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR015194; ISWI_HAND-dom.
DR InterPro; IPR036306; ISWI_HAND-dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR015195; SLIDE.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF49; SWI_SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 1; 1.
DR Pfam; PF09110; HAND; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09111; SLIDE; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 156..321
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 451..602
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 804..856
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1010
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 119111 MW; D0EB26FD32FECC76 CRC64;
MSEPEKKVKS EEERVEEEEQ GVFFGGNESL PDKQVESKEN DTNYEEKMQA DRANRFDYLL
QQTELFAHFI QPAAQKTPTS PLKMKPGRPR IKKDEKQNLL SAGDNRHRRT EQEEDEELLT
ESSKTTNVCT RFEDSPSYVK GGKLRDYQVR GLNWLISLYE NGINGILADE MGLGKTLQTI
SLLGYMKHYR NIPGPHMVLV PKSTLHNWMN EFKRWVPTLR AVCLIGDKDQ RAAFVRDVLL
PGEWDVCVTS YEMLIKEKSV FKKFNWRYLV IDEAHRIKNE KSKLSEIVRE FKTTNRLLLT
GTPLQNNLHE LWALLNFLLP DVFNSADDFD SWFDTNNCLG DQKLVERLHM VLRPFLLRRI
KADVEKSLPP KKEVKIYVGL SKMQREWYTK ILMKDIDILN SAGKMDKMRL LNILMQLRKC
CNHPYLFDGA EPGPPYTTDM HLVTNGGKMV VLDKFLPKLK EQGSRVLIFS QMTRVLDILE
DYCMWRNYEY CRLDGQTPHE ERQNSINVFN APNSTKFLFM LSTRAGGLGI NLATADVVIL
YDSDWNPQVD LQAMDRAHRI GQTKTVRVFR FITDNTVEER IVERAEMKLR LDSIVIQQGR
LVDQNLNKLG KDEMLQMIRH GATHVFASKE SEITDEDIDA ILERGEKKTA EMNEKLSKMG
ESSLRNFTMD TESSVYNFEG EDYREKQKMA FTEWIEPPKR ERKANYAVDA YFREALRVSE
PKAPKAPRPP KQPNVQDFQF FPPRLFELLE KEILYYRKTI GYKVPRNPDL PNAVQAQKEE
QSKIDEAEPL NDEELEEKEK LLTQGFTNWN KRDFNQFIKA NEKWGRDDIE NIAREVEGKT
PEEVIEYSAV FWERCNELQD IEKIMAQIER GEARIQRRIS IKKALDTKIG RYKAPFHQLR
ISYGTNKGKN YTEEEDRFLI CMLHKLGFDK ENVYDELRQC IRNSPQFRFD WFLKSRTAME
LQRRCNTLIT LIERENMELE EKEKAEKKKR GPKPSPAQKR KLDGAAESRG RKKKLKL
//
