ID H3AEP1_LATCH Unreviewed; 502 AA.
AC H3AEP1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Transcription factor binding to IGHM enhancer 3a {ECO:0000313|Ensembl:ENSLACP00000008112.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008112.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000008112.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01197404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01197405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01197406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01197407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01197408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01197409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01197410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01197411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01197412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01197413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AEP1; -.
DR STRING; 7897.ENSLACP00000008112; -.
DR Ensembl; ENSLACT00000008178.1; ENSLACP00000008112.1; ENSLACG00000007182.1.
DR eggNOG; KOG1318; Eukaryota.
DR GeneTree; ENSGT00940000157503; -.
DR HOGENOM; CLU_031638_3_2_1; -.
DR InParanoid; H3AEP1; -.
DR OMA; MAMPTIT; -.
DR TreeFam; TF317174; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF3; TRANSCRIPTION FACTOR E3; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 295..348
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 85..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 54648 MW; DBDE73C7E260DE9A CRC64;
LNSLLPESGI VADIEVESIS SSNPDNFYEL KSQPIAVRSS EGISLFMVTH TPANQQSPYQ
PLSLPLASTM SSRVLLRQQL MRAQAQEQER REQQQQQQAA QFMAERAVSN PSSPAISVSS
PVTRPTATQV PMEVLKVQTH LENPTKYHIQ QAQRQQVKQY LSTTLGNKVA TQALALTHSP
QSASAPEQGH PPGAGSTPNS PMAMLNIGSN SEKEIDVIDE IISLESSFND DMLGLLDAGL
LPSTLPVSAN LLDVYTNQGV SAPAIAVSNS CPADLTNIKR ELTGSVIQHQ SKQCKLYLFH
IIVERRRRFN INDRIKELGT LIPKSSDPIC QWRANQRLRG ALHSLRFIRP QSSVAMLSES
ETHWVFFGGR GGSVFSQELE MQARQHGLPV ASPSGLNMSK LAVEIIKQES DLKQGAIGFL
EPLAPLGLAS TTLDLNTFNF SDLDNPVMTF GLGLDPDPSI EDILMEDTLS PISASDPLLS
SVSPGASKTS SRRSSFSMEE ES
//
