ID H3AFI7_LATCH Unreviewed; 825 AA.
AC H3AFI7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
GN Name=LOC102366449 {ECO:0000313|Ensembl:ENSLACP00000008408.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008408.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000008408.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01157184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AFI7; -.
DR STRING; 7897.ENSLACP00000008408; -.
DR Ensembl; ENSLACT00000008476.1; ENSLACP00000008408.1; ENSLACG00000007444.1.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000161685; -.
DR HOGENOM; CLU_343449_0_0_1; -.
DR InParanoid; H3AFI7; -.
DR OMA; PEIKCHL; -.
DR TreeFam; TF330122; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000007444; Expressed in chordate pharynx and 2 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF10; NEUROFILAMENT MEDIUM POLYPEPTIDE ISOFORM X1; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 87..397
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 105..222
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 255..368
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 536..743
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 93778 MW; 0C43D4E607F03E46 CRC64;
MSYMDFLTTR PRRGAQGDHP RLQTRVPGSL SSGVPFPRLS SIPASANYIH RSNALLKREY
ISPTFKPSDS LEFTQIVGDL NVPNVTEKEI LQKLNERFAG FIDNVHHLEV QNSNLEAEIE
TLRCTQSSPS LAEFYEPYIR DLRELIQEVN SQKTQIQLAH QQLEEDLENW SQKCQAEAQI
REDTEANVRA LKKETGDANL LKLELEKKAQ SLADEIVFLK KNHEEEVTEL MSQMQDPQVT
YEMKGILKPN ITAALKDLRA QLEGHTNNNM QQAEELFKSR VAKLAKAAEI NNDALQTTRQ
EIIEYRKQLQ SKSTELEAVR GTKESLEKQL DHLEERHDAE IAYFQNTIQQ LECELKDTKW
EMANHLREYQ ELLNVKMALD VEIASYRRLL EGEENRITSV SGSFTAPIGL QEQVATYTAE
EVAKQKTDPV KIEPQYKFVE EIITETTKEI EMTDIEECQG LPETETSLEE EKLSSDQPIE
LEKVEETAKV VEALSEKVEE DQTEKHEEGK QETTCEAEEG KEEILAATAE VMREAQGEVL
GDKTVEPKVE TMEHGESLPS MEEDKSVSEE IPKEREEKDE GDEKRATTGS KEGKEVHVDI
EATKESEQGE EEEDKKEKQG DLESKLDATL EVKEKLGDHS KKEEEPLESI VGKEELITSD
EEQEKSIDEV KEENVRLLKS EVSLTTVEKD EEEDKESSKK AEKKEDEETV AKGSEKCEDS
KHVEKGEDSK SEGKQKEQTQ EAAIPPEEPR GQEAGKVQET SKEKAMEEYS KEAPKEPEEK
SQEDIESQAE VSQAVQSAEE TQVRDQQEEA KSDLSDNGKK QVHGD
//
