ID H3AG45_LATCH Unreviewed; 797 AA.
AC H3AG45;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Cadherin 15 {ECO:0000313|Ensembl:ENSLACP00000008616.1};
GN Name=CDH15 {ECO:0000313|Ensembl:ENSLACP00000008616.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008616.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000008616.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR EMBL; AFYH01145044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006003885.1; XM_006003823.2.
DR AlphaFoldDB; H3AG45; -.
DR STRING; 7897.ENSLACP00000008616; -.
DR Ensembl; ENSLACT00000008684.1; ENSLACP00000008616.1; ENSLACG00000007617.1.
DR GeneID; 102358618; -.
DR KEGG; lcm:102358618; -.
DR CTD; 1013; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000160118; -.
DR HOGENOM; CLU_005284_2_0_1; -.
DR InParanoid; H3AG45; -.
DR OMA; NVTVCHC; -.
DR OrthoDB; 5306553at2759; -.
DR TreeFam; TF316817; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000007617; Expressed in muscle tissue and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF300; CADHERIN-15; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..797
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579559"
FT TRANSMEM 616..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..163
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 172..272
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 273..387
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 388..495
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 514..603
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 797 AA; 87577 MW; 729ECB2894635CF7 CRC64;
MKDCVAVLLL TALLMQVSSL PEEGPPLLDK SPELYPWRRE QQQHAAEGDG VKRVKRAWVI
PPISVSENHK KIPLLLVQIR SDKQELGKIL YSIKGPGVDE DPVGVFSINR TTGHVFLNTM
LDREKNSKFN IMAYAVDLGG KTLEEPSPLQ IIVVDQNDNR PVFDFPYFIG HVQENSPPGS
FVTKVAASDA DDPETDNAAL KYRILDHGSN VPMFSINEDT GEIRTVAVGL DRELVSVYNL
TLSVTDMVGR GLSNTATTVI HVDDINDNAP EFTSAVFTME LTEGTAHMDV GRVSINDKDQ
LNSTNWRVRY TITDGDPEGV FAIRTDPETN EGILSVEKVL DHEVTDWLNL TISVANEAEL
SPSAPKPSLP TATIIVQVKD LNEPPSFAEN PKIIYVSEGT RVRELITHFH AADPDVKQSQ
NLRYSIEYDP ADWLTVDPNS GDIFANQDLN KKSPFLKNGW YTAVIIATDN AVPPGTATGT
LSISIKEEND FAPVMYPLTG VMCSEPGKGT GIIIGAMDAD LYPHAEPFHF QFSPNFPDYT
QNWTITPIND THAAVEVHRE TKLGLYPLPI LVSDSGNPSL GQQNFLNVST CKCDDNGDCK
AMLGALTGAG AGLSHGALVV ILASVLLLLL AILLVAIIEH HRHRALRKGL LAGSEDDVRD
NILNYDEQGG GEEDQDGYNM DQLRNPNEVF LPHYPHGKPP IRMDAPYNYA PPQYPRKPPS
NPNDIEDFIN DGLDAADNDP NVPPYDTALI YDYEGEGSVA GTLSSIASGS SDGEHDYDYL
NDWGPRFKRL ADMYGKQ
//
