ID H3AGP5_LATCH Unreviewed; 249 AA.
AC H3AGP5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Ribonuclease {ECO:0000256|RuleBase:RU003515};
DE EC=3.1.26.4 {ECO:0000256|RuleBase:RU003515};
GN Name=RNASEH2A {ECO:0000313|Ensembl:ENSLACP00000008816.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008816.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000008816.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA
CC hybrids. {ECO:0000256|RuleBase:RU003515}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077,
CC ECO:0000256|RuleBase:RU003515};
CC -!- SIMILARITY: Belongs to the RNase HII family.
CC {ECO:0000256|RuleBase:RU003515}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01319}.
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DR EMBL; AFYH01054235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01054236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01054237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01054238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01054239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01054240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01054241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AGP5; -.
DR STRING; 7897.ENSLACP00000008816; -.
DR Ensembl; ENSLACT00000008885.1; ENSLACP00000008816.1; ENSLACG00000007789.1.
DR eggNOG; KOG2299; Eukaryota.
DR GeneTree; ENSGT00390000010768; -.
DR HOGENOM; CLU_036532_0_3_1; -.
DR InParanoid; H3AGP5; -.
DR OMA; REECRFF; -.
DR TreeFam; TF314302; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000007789; Expressed in muscle tissue and 2 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR CDD; cd07181; RNase_HII_eukaryota_like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.10.460; Ribonuclease hii. Domain 2; 1.
DR InterPro; IPR001352; RNase_HII/HIII.
DR InterPro; IPR024567; RNase_HII/HIII_dom.
DR InterPro; IPR023160; RNase_HII_hlx-loop-hlx_cap_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10954; RIBONUCLEASE H2 SUBUNIT A; 1.
DR PANTHER; PTHR10954:SF7; RIBONUCLEASE H2 SUBUNIT A; 1.
DR Pfam; PF01351; RNase_HII; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51975; RNASE_H_2; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759,
KW ECO:0000256|RuleBase:RU003515};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003515};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|RuleBase:RU003515};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 30..245
FT /note="RNase H type-2"
FT /evidence="ECO:0000259|PROSITE:PS51975"
SQ SEQUENCE 249 AA; 28376 MW; B108FF2483C4100A CRC64;
RRMDLSEFER DNSRSCRLVS SVPELCRGEE CCLGVDEAGR GPVLGPMVYG ICFCPLSRKQ
DLEELKVADS KTLTEAEREK LFEKIDLAKD FIGWALEVLS PNVISTSMQQ RVKYNLNVMS
HDAAIGLIQY ALDSGVRLKE TFVFRRGGGK KNKNELNSLF KTSFLIYFLF FPVISYSKVA
RDHAVKSWKF VEDLGDINLE YGSGYPNDPK TKEWLAKYLD PVFGYPQFVR FSWSTAQTIL
DSKAAPVHW
//
