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Database: UniProt
Entry: H3AGW1_LATCH
LinkDB: H3AGW1_LATCH
Original site: H3AGW1_LATCH 
ID   H3AGW1_LATCH            Unreviewed;       771 AA.
AC   H3AGW1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   SubName: Full=Tubulin beta 3 class III {ECO:0000313|Ensembl:ENSLACP00000008882.1};
GN   Name=TUBB3 {ECO:0000313|Ensembl:ENSLACP00000008882.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008882.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000008882.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the tubulin family.
CC       {ECO:0000256|ARBA:ARBA00009636}.
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DR   EMBL; AFYH01099832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01099833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01099834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01099835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01099836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01099837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01099838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01099839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01099840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01099841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3AGW1; -.
DR   STRING; 7897.ENSLACP00000008882; -.
DR   Ensembl; ENSLACT00000008951.1; ENSLACP00000008882.1; ENSLACG00000007844.1.
DR   eggNOG; KOG1375; Eukaryota.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000159115; -.
DR   HOGENOM; CLU_015718_5_0_1; -.
DR   InParanoid; H3AGW1; -.
DR   OMA; HARHITK; -.
DR   TreeFam; TF300298; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   CDD; cd02187; beta_tubulin; 1.
DR   Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR   Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR   InterPro; IPR002453; Beta_tubulin.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR   InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; TUBULIN; 1.
DR   PANTHER; PTHR11588:SF43; TUBULIN BETA-3 CHAIN; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   Pfam; PF03953; Tubulin_C; 1.
DR   PRINTS; PR01163; BETATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SMART; SM00864; Tubulin; 1.
DR   SMART; SM00865; Tubulin_C; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR   SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        159..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        207..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        250..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          27..269
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   REGION          748..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        752..771
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   771 AA;  86754 MW;  2CD0A4070755AFCD CRC64;
     NATYSACQKF TIPHELFLTL GLLSLVENTL VMTAIIKNKN LHSPMYCFIC CLAVSDMLVS
     VSNLVETIVM VLMEQDVLVV KIDVLRHMDN VIDMMICSSV VSSLSFLGAI AADRYITIFY
     ALRYHSIMTV HRAVIIIVAI WVASLSSSII FIVYSSTNAV IICLISFFLA MLIIMAALYI
     HMFTLARIHA RRIITLHKTD TAPQTTSLKG AFTLTILLGV FIICWGPFFL HLTLIVICPR
     SPYCTCFFNH FNLFLILIIC NSLIDPIIYA FRSQELRKTL KEIILCYCCL SLANTDLKVH
     GLLYFGGVIL KRINLVERVL RGRLVQEKLL NTLLLCNSSK FWEVISDEHG IDPSGNYVGD
     SDLQLERISV YYNEASSHKY VPRAILVDLE PGTMDSVRSG AFGHLFRPDN FIFGQSGAGN
     NWAKGHYTEG AELVDSVLDV VRKECENCDC LQGFQLTHSL GGGTGSGMGT LLISKVREEY
     PDRIMNTFSV VPSPKVSDTV VEPYNATLSI HQLVENTDET YCIDNEALYD ICFRTLKLAT
     PTYGDLNHLV SATMSGVTTS LRFPGQLNAD LRKLAVNMVP FPRLHFFMPG FAPLTARGSQ
     QYRALTVPEL TQQMFDAKNM MAACDPRHGR YLTVATVFRG RMSMKEVDEQ MLAIQSKNSS
     YFVEWIPNNV KVAVCDIPPR GLKMSSTFIG NSTAIQELFK RISEQFTAMF RRKAFLHWYT
     GEGMDEMEFT EAESNMNDLV SEYQQYQDAT AEEEGEMYED DEEESEAQGQ K
//
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