ID H3AGW1_LATCH Unreviewed; 771 AA.
AC H3AGW1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=Tubulin beta 3 class III {ECO:0000313|Ensembl:ENSLACP00000008882.1};
GN Name=TUBB3 {ECO:0000313|Ensembl:ENSLACP00000008882.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008882.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000008882.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636}.
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DR EMBL; AFYH01099832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AGW1; -.
DR STRING; 7897.ENSLACP00000008882; -.
DR Ensembl; ENSLACT00000008951.1; ENSLACP00000008882.1; ENSLACG00000007844.1.
DR eggNOG; KOG1375; Eukaryota.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000159115; -.
DR HOGENOM; CLU_015718_5_0_1; -.
DR InParanoid; H3AGW1; -.
DR OMA; HARHITK; -.
DR TreeFam; TF300298; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02187; beta_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002453; Beta_tubulin.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF43; TUBULIN BETA-3 CHAIN; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01163; BETATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..269
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 748..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..771
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 771 AA; 86754 MW; 2CD0A4070755AFCD CRC64;
NATYSACQKF TIPHELFLTL GLLSLVENTL VMTAIIKNKN LHSPMYCFIC CLAVSDMLVS
VSNLVETIVM VLMEQDVLVV KIDVLRHMDN VIDMMICSSV VSSLSFLGAI AADRYITIFY
ALRYHSIMTV HRAVIIIVAI WVASLSSSII FIVYSSTNAV IICLISFFLA MLIIMAALYI
HMFTLARIHA RRIITLHKTD TAPQTTSLKG AFTLTILLGV FIICWGPFFL HLTLIVICPR
SPYCTCFFNH FNLFLILIIC NSLIDPIIYA FRSQELRKTL KEIILCYCCL SLANTDLKVH
GLLYFGGVIL KRINLVERVL RGRLVQEKLL NTLLLCNSSK FWEVISDEHG IDPSGNYVGD
SDLQLERISV YYNEASSHKY VPRAILVDLE PGTMDSVRSG AFGHLFRPDN FIFGQSGAGN
NWAKGHYTEG AELVDSVLDV VRKECENCDC LQGFQLTHSL GGGTGSGMGT LLISKVREEY
PDRIMNTFSV VPSPKVSDTV VEPYNATLSI HQLVENTDET YCIDNEALYD ICFRTLKLAT
PTYGDLNHLV SATMSGVTTS LRFPGQLNAD LRKLAVNMVP FPRLHFFMPG FAPLTARGSQ
QYRALTVPEL TQQMFDAKNM MAACDPRHGR YLTVATVFRG RMSMKEVDEQ MLAIQSKNSS
YFVEWIPNNV KVAVCDIPPR GLKMSSTFIG NSTAIQELFK RISEQFTAMF RRKAFLHWYT
GEGMDEMEFT EAESNMNDLV SEYQQYQDAT AEEEGEMYED DEEESEAQGQ K
//