ID H3AGZ6_LATCH Unreviewed; 2955 AA.
AC H3AGZ6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 18-JUN-2025, entry version 59.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSLACP00000008917.1};
GN Name=CENPF {ECO:0000313|Ensembl:ENSLACP00000008917.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008917.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000008917.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
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DR EMBL; AFYH01094288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLACT00000008986.1; ENSLACP00000008917.1; ENSLACG00000007875.2.
DR GeneTree; ENSGT00730000111187; -.
DR HOGENOM; CLU_000551_0_0_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000007875; Expressed in pelvic fin and 1 other cell type or tissue.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0000922; C:spindle pole; IEA:TreeGrafter.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0051310; P:metaphase chromosome alignment; IEA:TreeGrafter.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:TreeGrafter.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:TreeGrafter.
DR Gene3D; 1.10.287.1490; -; 2.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874:SF10; CENTROMERE PROTEIN F; 1.
DR PANTHER; PTHR18874; CMF/LEK/CENP CELL DIVISION-RELATED; 1.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
DR SUPFAM; SSF57997; Tropomyosin; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 1..305
FT /note="Centromere protein Cenp-F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1901..2042
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2137..2276
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2807..2849
FT /note="Kinetochore protein Cenp-F/LEK1 Rb protein-binding"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 205..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1697..1716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2663..2688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2722..2776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2897..2955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 20..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 162..189
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 285..625
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 654..741
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 781..1270
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1298..1395
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1436..1463
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1487..1620
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1849..2051
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 206..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..274
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2675..2688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2722..2755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2902..2917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2945..2955
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2955 AA; 342120 MW; A2E473081652BAB6 CRC64;
MSWAIEEWKE GLPSKALQKI QDFESQLEKL KKERQQKQFQ LESLEAAFQK QKQKVENEKS
EVTALKRENQ SLVESCDNLE KSKQKISHDL QVKELQVNFL EGQLATCKKQ IEKLEQEMKR
SKCEIERSQQ PLLLGDLQPC ATPEKNFAVP VAPSRNYNDS KVEELQEKYN KEVEERKRLE
AELKIMQAKV VNQSQGNVNR RDIARQQASS SVFPWQQEQT PSHAASNSLE TPSRRGCTTS
HFPWEREETP SMYCQRSAKK TASNSSFNES SSNSPQNDLL KVQNQEELNS KVTELELRLQ
AQEKEMKTCA NKLQEVQAHF EKAKLELSEK DKALNKYRDE VTKMTTQLDQ SSSKCEVVEQ
KLKQVSEELI CQRQNTDSAR HTMEQRLKEK EKEYQQELCQ QLHSFQILDQ QFKQMKTELQ
QAKNDRNTLQ AEIDKLSTMK QRAEKEVEDM KQTLFRTEQT LQAKEKDFKK TVEEVQKEKN
NLHCQFEQSS RQVHQQEEEL KMTQQHLKQS QSLVEELKSK NIAREVQLLS FKEKLDKQEQ
SLNTDLENLR QTVADLQKQQ DSAQDILTKR EKEMEEMNNK IITMEKETEE LQNALCLKYN
ECAELKRETS LLSEWKNKTE NLKNQMLCEK EGMLKEIQEL EKCLESHQYD NERIKVLENE
KQNLCLQIEN YERLLDCKSA DLESQKQIYE KLRKTAEQAD QKYSKEKENM CLQVIQLTAQ
ANGLEKKLQL ETNKILKMEQ SYSELCAEYE RATNLAKSKE SVIELKEAEM LNLQNSLSET
IIDFEKQLAK VNSEKSDLIK EHENAVLGKA VEAENMKLEL EKCQNDIAFS KEQISSLECD
LKLQKDLNSE LESRCEELMK VKDELEEKLV EVAKNLEIVQ AEAKEERELK ITVSAQQQRV
DDLLATVQEK EMSIQKLTSE QERKESCLQS LQSSNQLLEV QVQQLNIQSE AQRQEKEDIL
ASIFSNEKEV ENLAKENEKL KEVIDTLSQE KQVLLEKNSN FANMVKEKEA EVSELSTRRA
EEHQTILENN VKLESELANL QKKYSCMEET KDELEVQIKE KTEKLEEQER KFNKQCAEYL
SKMEHYEEAN QSLVKEVEKV QSSLNNKLEE TTQFKERLIV SEKETENLRK KLSDTTEGYK
ELQEMLRRLQ QENELLNQQN QQLKSSELAK EKTQYGEELR EAMREKESDL SKIQVQLEML
QMDLEDKEVC IESYSTQIEQ MEATVKKMES ELRESEEQKT IVREEKNSLC KELEATKSKL
SDALEKEQIL KLCAEHKEQS EKELAAVSQE YKSCQLLKTK LETSLQEVSS KCEELEKMYE
RMQTEKSELI SELSNLRTQC TTVLDENSGL ADKIKHLENE VNLSKDESTA LHSKLMSLKD
ENEKLKEWAK QEECEKLKLC NKEIERHLFE VNEKLSCSQK EYDIVQEQYC CAMSKVSELQ
SLVETLEEEK SVLVAKLEES AEVDKADELQ TQLNMAERKL FDTEIILSKT NVEKAALEAE
VNILETSLES AQLQLTEQKA QLQHLEQLIL ERETEVMDLK EQLNDFKGNL VSKENNASQT
EGNLPKEIEE LKILSETYET GIKKLEEQLQ MQKDARNGEI QELSQTLAAT KNELTCLQKQ
HSSEIDQWQQ KLSSMTLEME TKLAAERQQT EILSTELKGA RIQIQHLDLS SHSLLCAETE
EDQKEEINEN LQYINSFSKD PQSEPQSNER DGIETENTID ISQENISRLD VETETDSVAD
NTVECLRATV EFLCLDSNTS THQEDFQETH VVPESCTSQP ENVSSKQEFL SQELEEYKKD
DILLKEEQHL YSRLDSQQLQ STSQNSACTE LQNVVYKLEE EKSVLSDRIK STNLENQKLS
ERIKDLEKEL NSMTSEQEVY KARLSDVTEM LHSLEMVKGN WNEKYLEVEN ELKRTRSEKA
NLEKHILSME ADIEEMQIAK TSLEKEAANS SKCISRLGEQ LSVATADKNQ LSQELESSRE
IQEELEQISQ NLKEKLEQLA SDKVNYTEFI KVLEAENKKL TKQLEITKFD VEKLSKERNS
ILEQLDCLEK NVLSDEKGEL QKQFDQRTEE KEVLLNECET LQGKICALEM ENSRLSQSLE
SSLVEKGEIA SRLNSTQEEV VQMRHGIEKL KVRIESDEKK RHHEAEKLKA SERKADSFQD
KVEKLQRELQ MSEESLEGMV LEAETVKEEM EKLVTVKQEI SKKLQILETE VNTLSSERDL
LDKELQQKQL KISELEGSCM DITNLLKKVE EEKLQVMQEH VVSQKALKSE LMELNEKLKI
CSEELENWRA KEQDWLGQIS GLECEKTELS QQLQQKESSF AELHSANVSL TQDLLASKQE
LNEQVKANNR LQQEVTDMQQ WKQKISEQLS NVEAEKVSLE KERNQLQTIT TESEQRVQAL
EAKNFKMQGT IEGLEGSQQL LEDELQSAKL QNSALLEQIQ KITENDSRVR SDLNAANQKI
EKMQEECNLE RSTLVAQINN AQQQEESYKV QLDLVTSEKE EMKKRLQHLQ NELQISEEKI
KEERMEYQHQ LQEAEEKQKT LLKEGREKYE AEVHTEREKL ITMRQMLNDH ILEINNLKSA
KEQLNAALRK AESKLEQLNE KKVEDLKTTI VQLKKEKESA VSKLQLWMRS CKQMEQEKEM
LLKDIEQQDA LLNKLKKNEK IETDTNADGV SSELEELRET VEEKTREADE SMEKYCNLII
NYHKLEEANE TLKNRIAFLS SQLKQPGSQD SNSTAKTTPD NPPNSKTGNL KTGKTSPWDR
SRPCNKRHRT VEPKEDGLEL EKVEATECVS KRIRNGKENG MSRHSAGGDN VEFKPEGLPE
VVKKGFADIP AGTASPFILR RTTLQRRSPR LAAQKTSPIT QVVQKVALEN QAQNSKTPGG
SKLQQVKEVS SFSLGSVLGP VASTSGSPLS SVINSPKKTA FQIPSGSAPT RRSRRSPSTR
KYPEQEEEEE NCNVQ
//
