ID   H3AHG6_LATCH            Unreviewed;       856 AA.
AC   H3AHG6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
GN   Name=LOC102352708 {ECO:0000313|Ensembl:ENSLACP00000009087.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000009087.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000009087.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   EMBL; AFYH01178461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01178462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01178463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01178464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01178465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01178466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01178467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3AHG6; -.
DR   STRING; 7897.ENSLACP00000009087; -.
DR   Ensembl; ENSLACT00000009156.1; ENSLACP00000009087.1; ENSLACG00000008021.1.
DR   eggNOG; KOG3511; Eukaryota.
DR   GeneTree; ENSGT01030000234563; -.
DR   HOGENOM; CLU_010702_0_0_1; -.
DR   InParanoid; H3AHG6; -.
DR   OMA; CECAEAD; -.
DR   TreeFam; TF324918; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00089; PKD; 2.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        759..777
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          495..536
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
SQ   SEQUENCE   856 AA;  95284 MW;  FC68B1FF1E6FBBB8 CRC64;
     AQYVTCKVQN CTETSRAKPF PGLIASNSLV VQDNYVFVQV SSGGRRNYYV SHKRQAFAKM
     KLPKYSLPKD MHIISTDEDQ VFAAVQEWNQ NDTYNLYISD TKGVYFTLAL EDVKSSRGPE
     GNIMIDLYEV AGIKGMFFAN KKVANQVKTF ITYNKGRDWR LLQAPAIDLR GNYIHCLLPY
     CSLHLHLKVS DNPYTPGTIS SKESAPGIIV ASGSIGTGLS VNDKKMFISS DAGNTWREIF
     EEDHSVLYLD RGGALVAIKH TSSAIRHLWL SFDEGRSWNK HSFTSVSLFV DGVLGEPGGE
     TLIMIVLGHF SYLSEWQLVK IDYRSIFDRR CAKEDYQKWQ LHNQDEPCIM GEKRTYKKRR
     PGAWCMLGKA SAETVTSESC VCTESDFECD YGYERHTDGK CLPAFWFNPS SMAKDCIIGQ
     NHLNSTGYRK VGSNNCIAGV KEQYTPKLQM CPGKAPQGLR IVTSDGKLTA ESGRNITFMA
     QLEEGDAQRI NIQVDFGDGT AVSYANLSSV EDGILHVYKA AGIFRVTAYA ENGLGSDGAV
     LYLHVTCPLE NVHLSVPFVS VKNKRVNASA VLWPSNVGAL TYIWWFGNKT EPLITLKESI
     SFTFTTEGIN SITVQVSAGN TVLQDTKSVA VYEYYQSLRL SFSSNLDEHN PGISEWRKDI
     GRVVKRALVQ ATAVEEQQVL VAILPGLPTA AEVFILPHED RRRRGNIAEL EKISEILVSA
     LNQNKIHFDL KPDVKVIVYP DHLTAAPLVE LGPGHSGPAL LMLLSVVMLG LAVFVVYRFK
     RKIPGINVYA QMQNEKEQEM ISPTSQSEST PNITQIELTS PEQLLHEELD TRIMEGCSTT
     VAVNRSTKEI PTSMNV
//