ID H3AHI4_LATCH Unreviewed; 994 AA.
AC H3AHI4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=KN motif and ankyrin repeat domains 4 {ECO:0000313|Ensembl:ENSLACP00000009105.1};
GN Name=KANK4 {ECO:0000313|Ensembl:ENSLACP00000009105.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000009105.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000009105.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01209630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01209631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01209632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AHI4; -.
DR STRING; 7897.ENSLACP00000009105; -.
DR Ensembl; ENSLACT00000009174.1; ENSLACP00000009105.1; ENSLACG00000008036.1.
DR eggNOG; KOG0514; Eukaryota.
DR GeneTree; ENSGT00940000158468; -.
DR HOGENOM; CLU_004269_2_0_1; -.
DR InParanoid; H3AHI4; -.
DR OMA; QSCQGDE; -.
DR TreeFam; TF324499; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047184; KANK1-4.
DR InterPro; IPR021939; KN_motif.
DR PANTHER; PTHR24168; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24168:SF24; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF12075; KN_motif; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 832..857
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 904..936
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 937..958
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 108985 MW; 1967762BFDA8BDC9 CRC64;
VIFVPGNGDS SKTSENGNQQ KQLPYSLETP YGFHLDLDFL KYVDDIEKGN TIKRVHIHRK
AKQPKYSTLP RNFSIPNNGS RSYESSFSSG NWTSSYLPAP KNKVVKTKDV LDFAAADSTT
LAGSSNTCEL NFKVGSTYQE IKGEGKEACY GEPSALSRGR PQLLRASSMP VTVLQRKDSE
EQCSTPTDVQ HSNRTSCVDN IFNPANESIS QNSSKNFVLT KSEIALQRIK ELEEKVKSIP
NLKKQILLLK EEKNVLITQL QNQSFATEFK DAQSLTLHKG STKNQNIPSL DVTIPETSMH
TKQNTNVMSS KHLELNISEN EMESSVRAEV GSTAVTNTEN ELCLESSTLT EPFTVITLKA
KITVLENQLN DARKELEKNS DTHKQQNEEH KAKNINPHQL PGQKIRMDSK PAVQEEKCIL
VDKKASDNHK CSDAAVNTEI VQEGMQKETC DKGITVDIHL STQSVGCGDC TVDIFSPVKE
VHSMGVQTDC DDTTTDSSMS SGADRCDDKA KEAVIVVTDK AVDIDQTLLL KSSIHKLSSS
KETTVVTQDP ISDDLGNKEQ VKDETQQYPA IVGQYVNKIQ VLLQEQWACL EHGYPELANA
LKQPASKISS IQNQLMSSLN VLSSVYSTQT SSEEKNVGKS SPELVRSPTT MLKSIMKKKN
CNPEDNGTKK NLQFVGINGG YETTSSEDSS GEESSSDDNS GCDSVEKCDS SVENHLQAAS
NGSEAVSKTI QDHIQQYHNI NPGTPSPHHH CARVQIGEDF LAACLLLSHH LSEIRTTTDR
QLKQSLTAVC QEWFAVSSQK LSVPEPVEDY LKEFKSISLE LLMLIMNIAD GNGNTALHYS
VSHSNFQIVK LLLDTGVCDV DCQNKAGYTA VMLAPLAATE TDEDMEVVLQ LLKQGNVNIQ
TSQGGQTALM LSVSHGRFHM VKALLSCGAD LNLQDDTGST ALMCACEQGN VEIVKLLLTQ
PSCCVELTDK VGRNAFSIAL EVSHKGIAEL LNAH
//
