ID H3AI37_LATCH Unreviewed; 850 AA.
AC H3AI37;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=LOC102347299 {ECO:0000313|Ensembl:ENSLACP00000009308.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000009308.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000009308.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01208814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AI37; -.
DR Ensembl; ENSLACT00000009379.1; ENSLACP00000009308.1; ENSLACG00000008210.1.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000182788; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; H3AI37; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF0; VOMERONASAL 2, RECEPTOR 23-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 594..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 705..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 749..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 590..850
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 850 AA; 94356 MW; B51FC6AC8AF3AE57 CRC64;
VFLLLSSPVH GAAQTGCTLR SLNTKGYFRA GDIIIGGLFP LYYNKVLPDA NFTELPKVAR
CEIFRVSHYQ WLQSMVFAIE EINRNTKLLP NITLGFAIYA SCGMPVRAIK GTMWMVTGQE
EAIPNYRCQV HYPLAAVIGD APSSISMPVA NILGIYGYPQ ISYGSSVALL SDKHMFPSFF
RTIASDGFLS LGLAQLVMHF GWTWVGLIAE GSDFGQQGIQ ILREELVKLG GCIAFSEMIP
LVHSQEIIHN IVEIIKKSVT NAIVVFANEA SVAPLMEEVE SQNITGKVWI AMDSWDPLSL
FSPKKLLKTL VGTIRVVVHK GKMPGFQEFL FALHPSKSPN DIFIKDFWEE SFGCTWLNIN
QTLSEEFNKG INLCTGTEKL TIVKDGFLDV SNLRLTYNVY NAVYAAAHAL QDLLACKPAE
GPFPNGSCAD INDFEPWQLL HYVKNVHFKN NAGDEIFFDK NGNPPPAYDI VNWHLLPDGS
AREVKIGSID FSATQGLHLV INESAIMWNG GNTQIPRSVC SEGCSPGYRK AIRPREPICC
FDCVLCANGE ISNQTDSTDC MKCPDDQWSN DRQDMCIPKT FEFLSYKDPM GETLSVLASF
FAVIPITILC IFIKYRDTPI VKANNRELSY LLLLALVLCF LCSLIFIDKP RIWTCMARQA
AFGIIFALCV SCVLAKTIMV VIAFNATKPN SNLKKWVGPK LASSIVLVCT VIQVIICVAW
LATFPPFPEY NMKSQIGIII IECNQGSSTA FWCVLGYMGL LAIICFIVAF LARNLPGSFN
EAKFITFSML VFVSVWLAFI PAYLSTKGKY MVAVEIFAIL ASSAGLLACI FFPKCYIIVL
RPDMNTKEYL
//
