ID H3AIX0_LATCH Unreviewed; 3230 AA.
AC H3AIX0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0000259|PROSITE:PS50188};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000009591.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000009591.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01092209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLACT00000009664.1; ENSLACP00000009591.1; ENSLACG00000008457.1.
DR GeneTree; ENSGT00940000166813; -.
DR HOGENOM; CLU_000091_0_0_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000008457; Expressed in chordate pharynx.
DR CDD; cd12881; SPRY_HERC1; 1.
DR CDD; cd14401; UBA_HERC1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035768; SPRY_HERC1.
DR PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR22872:SF6; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR Pfam; PF00415; RCC1; 5.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 371..420
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 421..475
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 476..528
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 529..576
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 578..629
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 630..680
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 681..733
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1906..2107
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1381..1414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2185..2207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2320..2394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2525..2551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2320..2369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2370..2387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3230 AA; 354905 MW; E1207B0980D68E4F CRC64;
MVLCQTHWML KWMDHLHGSW ALQDSECIAT REGASQLFSR LLNNKEVVGV SQLAHHLLWP
QLPDFEQESC AEEERERYLS ALLQSQHHLS RRVLANMPYT GALQKRLVVL QRIYCALSTR
YHECLRPCTQ GQVESGEGRL ELSGEAGKQS SKVRSGNEVL MELGLKTGLS LIFTLLQQNW
QRAGPDPGPN LCNDVLNTAS MVLASLPSLS LANEHKLPPV GQDCLEQVTN FLKRAMMPSS
GADALGRRRA AELLLLLAVQ RGSLKFILQW IEAALAASDS STATNRMPSS VEEGGTIGYT
NFLMVLEQMR LSSVVASECP AGQELKRPPD EMCSLTEAAI GVLEQVCELS SECLTSQKGG
SSSPCRKTEM MSVYVWGSNS SHQLAEGTLE KIVQPKLTQG FTNAQTIEAG QYCTFTVSSD
GAVRGCGKGS YGRLGLGDSN NQTTLKKLSF DPHRAIRKIS SSKGSDGHTL AVTAEGEVFT
WGDGDYGKLG HGNNHTQKYP RMVQAPLFRK VVVCVSAGYR HSAAVTAEGE LYTWGDSGCL
GHNDGENRSV PALVRDISGV GQVACGSSYT IAVSQDGRTV WSFGGGDNGK LGHGDTVRVY
RPKVIDALQG FCIRKVCASS QCSFALTSAG QVFVWGSGSC LGCGSSDVMA LKPRLVQDLT
VTKIIDITCG DSHCLALSQD NEVYAWGNNA MGQCGQGHTT TPVTKPKKVI GLEGIAIQQI
TAGTSHSLAW TAPPNDRNLV PWHRPFCIDL EESTFSQLRS FLERYCDGIN GELLSSPFSS
IREHHQFVLL CLKLLSTHLS LAQIGGIGPA LLGAEGRPIR NLLFRLIDSA VPDSIHPAVV
ETLSIGASLL LPPLRERIEL LHSLLPQGPD RWDSLSKGQR MQLDLVLSNL QDQSHIASLL
GYSSPRALGR AMPSINATSQ ACANSGSSDH FHLVDLLLKT LLRNISFYTD RVFGELEKNS
DKKQLVTTAT VTVPADSEPP THIHHLLSAL HRHLLAHCYT NMESEDEGIV RLLHAHLGLL
LPLCSENYKR STCLLKISSQ NHKLVGRLQA LLFSSAAGSL LCQVVHSLLL LPLHITQPLL
DRLLELLMAL DQLNQHLPST IQLEEEEMKG TYTGGEITHT IITDRRVWLL DLERSLALLI
GNCLGGMLQG PPPSPEEIIS ENWLQNPLLS SGLESHAEQL DNQMAWLIEK GLCGQTEQRA
LEHFASEKNR VLMDLALGSC REPVDGAWRR MKEYARSKDW ETRIEYESSL LDIVSRFTFA
ALLKHTGLLE EACQDDRHDP SDAMLAVYHS VYRLRCSLHK QKDDDINATA CHAGSSTRYT
SVNAESPGKW RRLQEEEVTH QPLGAEERQH VETENGISSM SNVLQCLMAS QDAMRLQENE
TVYETSAGSS HPSSTHSMDS LETEQGPVTT GPEERTQLEA PGSFSALCRS IISNAAFLIV
GLQAACREDA SSREKTENSP SQERKWQRVA GAQRGLSLGS EYKKWKLESV GQLKTQCSVS
YSRLGLPLCP LGMVKEAWEK LRQCISPTDH LSLMPCSSLL NNAYQFLTRG LVRMPSWGQP
ELRVIMTAMV KQQQRAELRL EAMHQICSFV SEMEGKDSGG EGLGCPGLLL TAQLHFLMGC
FSQETYLVSS LSQGKKDLQH YTTGIQCVNR NLQRELRMTV HSLHQQMAAA MRRRLAAQEE
VSAADQYLLL VTLVVLSVRY QPEDLLTLIG TGLMDPLSKL ATSCVLLNQR WLMAALSGQA
QLSLALQLGG ARLLQILALT ASLCEDSMQA DVVQPLMDAQ CQQLRHLLHL IYGMRLLESD
KPLCMSESTS SKSWGGCIDS NEMHVLETQL GDFLVFLRRV ISPRKSVGSA VSRKWIDPLL
TVATQKRASG EPLIKSLRTR LLVLQILEAL LPACTDTDLI KETVEKLFNL LSTCMWEEPL
VPTTGMEGNQ TNQCPNSDGK EDIIPIQEFS FDPEKLVCCS LENGNVLYHE SGGKGYGLAA
ISITTGCFSW KFFIGGESRG NEGTCVGVSR WPVRDFNHRT TSDMWLYRAY SGNLYHCGEL
GKTLPSFTQG DHITCILDME ARTLAFAKNE EEPRIAFENI DGTELYPCVV FYSNNPGEKV
VISDLKLRGS PQELHAGEPH CSPRMAVLAE ATVQLLRTLH QYDTWTPVIN SHMTSRLEMI
GSLVKEPGAV KMSKVASKTS LRKCSAEEKD GVTEEKTSRD KEKLQSMSEL TDSQLRALCS
NVWPVLAVIG GVDSGLRMGG QCKHKPTGRK ATLLGVQKQG SKSVKVQWEE ADMTVSDALL
SSLEPEEPPQ FSASSLGLLS ASTLMDLVFL SGVREEMERS GGKGCRRAEL ESGMKSDVEK
SLDEDIGRAM LVEEEEEESI QKSDREVPDR GNQNQNPVQN QGVHSSHAHP VRSPPESFSL
ELRIIRLSYL MVGAMKTLSV LLSHSQYTDL FLVHRLPGAS GTSSSDPARI QGLPELQSIL
QFLVRSMVKR AVRPSPIKRV TSLADLERAQ TMVYCRTLDW LQQDPGVKEV RRESVLLQPP
LPQTISESSS SFSLRSCSSE GTTTSPLSNV ASASSSINDL GSSIFSALHN SGVDNFNPFL
PINLIQQMVL VRFPSLAGLL NNPVLHSRLH VMSSAGSDGY VDRRTFCEEI QTTSSRASTH
CDRAPPVAAP LLEMGFSIRH IYKALETTGL SEEADPQSIE QLASWMLEHP LPEHEEVIVY
SSAANQREQE VVTPGSSRGM EQSTLLVPIQ RPEDATEINI SSLDQVERDN IIDVHPTRTR
PAPARRQRPV PICRQSQRRP GARSQHVLQS VPRTEPAVSV GWYEMDSSSE LYPDGEGELG
VLEDPVLEDM FEESLSSETA ASEDQTYTFL QSADREAEPE GMVLCELCGT FTLQFNTHMR
THHPGCGENT GRQGYRSNGM YVDGWYGGEC GTGSPYYLMC TSCREKYLSV KSKDKPAKQY
RSKGLALDLI GRPETASEED WELSDLEDGG KLIGQEDVGV YSGLLGLSER KPVPEPVRFA
EQDPLGAFLL RTNVPEEMLL QKGADALDEK SQSGKLTLGE QAASLRDPQD RLLALKRITA
AAQVLLAHSM VIRALSLVTA SGPMCSQPIF LEVLGLSDIH VLVRMLCLAA AGRPQLTSAT
MRERNGSFFT LTHLSSAISC LVLNNPGAYR ALMDICTQNL ISAACGLNMG IITNPIQRLR
SSATASKGLV NESRQTGSSG FLVTQVLVCL LTEKGLRQRQ EREDAELKGE
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