ID H3AK24_LATCH Unreviewed; 206 AA.
AC H3AK24;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=RAB7A, member RAS oncogene family {ECO:0008006|Google:ProtNLM};
GN Name=ZGC:100918 {ECO:0000313|Ensembl:ENSLACP00000009995.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000009995.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000009995.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270}.
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DR EMBL; AFYH01161495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006005473.1; XM_006005411.2.
DR AlphaFoldDB; H3AK24; -.
DR STRING; 7897.ENSLACP00000009995; -.
DR Ensembl; ENSLACT00000010072.2; ENSLACP00000009995.2; ENSLACG00000008809.2.
DR GeneID; 102352152; -.
DR KEGG; lcm:102352152; -.
DR eggNOG; KOG0394; Eukaryota.
DR GeneTree; ENSGT00940000155864; -.
DR HOGENOM; CLU_041217_10_6_1; -.
DR InParanoid; H3AK24; -.
DR OMA; FSHINSW; -.
DR OrthoDB; 586759at2759; -.
DR TreeFam; TF105605; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000008809; Expressed in pectoral fin and 6 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd01862; Rab7; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47981; RAB FAMILY; 1.
DR PANTHER; PTHR47981:SF13; RAS-RELATED PROTEIN RAB-7A; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
SQ SEQUENCE 206 AA; 23258 MW; C0BEDB6B26E6A9A0 CRC64;
MASRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV MVDDRLVTMQ
IWDTAGQERF QSLGVAFYRG ADCCVLVFDV STPNTFRTLD SWRDEFLIQA SPRDPDNFPF
VVLGNKIDLD NRQVPTKRAQ AWCQSKNGTP YFETSAKEAI NVDQAFQTIA RNALKQESDV
DTYDFPDQIK LDRSDRPQTA SDGCNC
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