ID H3AK67_LATCH Unreviewed; 1163 AA.
AC H3AK67;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=ALF transcription elongation factor 4 {ECO:0000313|Ensembl:ENSLACP00000010038.1};
GN Name=AFF4 {ECO:0000313|Ensembl:ENSLACP00000010038.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010038.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000010038.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR EMBL; AFYH01139594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01139595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01139596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01139597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01139598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01139599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AK67; -.
DR STRING; 7897.ENSLACP00000010038; -.
DR Ensembl; ENSLACT00000010115.1; ENSLACP00000010038.1; ENSLACG00000008849.1.
DR eggNOG; ENOG502QR32; Eukaryota.
DR GeneTree; ENSGT00950000182974; -.
DR HOGENOM; CLU_006484_0_0_1; -.
DR InParanoid; H3AK67; -.
DR OMA; RTPVCIF; -.
DR TreeFam; TF326216; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000008849; Expressed in post-anal tail muscle and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF15; AF4_FMR2 FAMILY MEMBER 4; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 898..1161
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..875
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 127735 MW; BC06EDD5CD61AEE9 CRC64;
MNREDRNVLR MKERERRNQE IQQAGEAFPA NSPLFPEPYK VTSKEDKLSN RIQSMLGNYD
EMKDLMGDRS LQKLVGIPKP TVPSTPDEKS NQSFFGESRH NSSHQGSKWT PVGPAPGTSL
QSQKRSSSGL HSGQRSSNSS GSSGSSSQRH DRETHSSSSS SRKKNQHSTE HSKSHSSSPS
KPPAVGTLSS SHSRSQGSDH HSKDRQRSKS PHDPDANWDS PSRVHIFSSS GQHSSQSFPP
CLMSKSSSML QKPTAYVRPM DGQESMESKV PSEHYSSQPN STSMSEIKSS SKAHLTKLKI
PSQPLDATMS GDVSCVDEIL KEMTQSWPPP LTAIHTPCKT DSSKFPFPTK KDTQHSNFAV
GTQKRYNAPS KTSSSGHQSK SMLQDDLKLS SSEDSDGEQD SEKPVPRNTP GSNSDPTQHN
GEGADNSRDD SSSPSGSESS SGSDSESESS SSDSEANEPS RSASPEPEPP PTNKWQLDNW
LNKVNPHKVS PASSVDSNVP SSQGYKKENR DQSTGSGYSA QSGSKDSSAS TPGRDSRATQ
KGSESSRGRQ KSPAQSDSST TQRKTVGKKQ PKKAEKATLV EEPRGGLKVE SEIPPEMPTS
IPPNRHKAAT KGSRKPNIKK EPKSSPRPAV EKRKYKSSSK PPQNKSREII ETDTTSSDSE
ENENNSEGRT SNNKSGLEEE ESFLRQRMFS PMEEKELLSP LSDPDDRYPV VQSLIVKIDL
SLLSRIPGRP YKEAQQPKVE KKSLQEKHTR ESLKQASDKS SNKGKRKHKN EDESGSSENK
KSKLEGRGSS SHKTSTNKES TKHVAEKEKE PLPSPSVPLP QKESKTEHQS RKRTVSQSSN
SKLGASSNKE SGGSSSKGNS SKHKKTEEKA AGSAKEGKVK VPSSAANCPP PSAPSADMKL
RRQKLTFDDR VYSADHYLQE AKKLKHNADA LSDRFDKAVY YLDAVVSFIE CGNALERSAQ
ESKSPFPMYS ETVELIKYTM KLKNYMAPDA TAADKRLAVL CLRCQSLLYL RLFKLKKESA
LKYSKTLTEH LKNSYNNSQA QSPGRLFSKP TGMPSPVSPK LSPGNTGSYS SAANNPSGSS
SSVTIPQRIH QMAASYVQVT SNFLYGTEVW DQAEQLAKEQ KDFFTELDKV MNPLMFNTST
MTDLVRYTRQ GLHWLRLDAK LIS
//
