ID H3AKD7_LATCH Unreviewed; 330 AA.
AC H3AKD7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Chimerin 1 {ECO:0008006|Google:ProtNLM};
GN Name=LOC102367675 {ECO:0000313|Ensembl:ENSLACP00000010108.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010108.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000010108.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01066932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01066933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01066934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01066935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01066936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AKD7; -.
DR STRING; 7897.ENSLACP00000010108; -.
DR Ensembl; ENSLACT00000010185.1; ENSLACP00000010108.1; ENSLACG00000008910.1.
DR eggNOG; KOG1453; Eukaryota.
DR GeneTree; ENSGT01030000234635; -.
DR HOGENOM; CLU_015883_0_1_1; -.
DR InParanoid; H3AKD7; -.
DR OMA; RVTCANE; -.
DR TreeFam; TF342052; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20806; C1_CHN; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46075:SF2; RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 76..126
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 139..330
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 330 AA; 36856 MW; 97CC5819D68C9DE2 CRC64;
MPAKGSESCS EMQVVPLVGL KPAERGQAPD LLAMALRVKT GGLWRPLKML ACSQLKPLAR
KASLKDGERH LQSERAHNFK VHTFRGPHWC RCCASFMWGF ITQGVKCTDC GINAHKQCAK
LVPHDCQLDS RQLQKVYGCD LTALLKAQAT QRPLVVEACI HEIETRGLRC EGLYRVSGSS
DQIEALKTAF ETAGVDASQA VKGCEDVHTV SGALKLYLRT LPAPLITYST YYRFIEAVKV
PCPEEQSVRL HNLLEYLPPA HLETLRYLIA HLRRVTHYEK DNLMTAENLG IVFGPTLMRP
PGHDPLAVLN DVCYQRLVVQ HLIQHEGVLF
//
