ID H3ALH0_LATCH Unreviewed; 422 AA.
AC H3ALH0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=SUFU negative regulator of hedgehog signaling {ECO:0000313|Ensembl:ENSLACP00000010491.1};
GN Name=SUFU {ECO:0000313|Ensembl:ENSLACP00000010491.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010491.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000010491.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01182337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01182338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01182339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01182340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01182341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01182342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01182343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01182344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01182345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01182346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3ALH0; -.
DR STRING; 7897.ENSLACP00000010491; -.
DR Ensembl; ENSLACT00000010570.1; ENSLACP00000010491.1; ENSLACG00000009241.1.
DR eggNOG; ENOG502QT57; Eukaryota.
DR GeneTree; ENSGT00390000009747; -.
DR HOGENOM; CLU_033906_0_0_1; -.
DR InParanoid; H3ALH0; -.
DR OMA; CQIVGVT; -.
DR TreeFam; TF324548; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000009241; Expressed in muscle tissue.
DR Gene3D; 3.30.1360.230; Sufu, C-terminal domain; 1.
DR InterPro; IPR020941; SUFU-like_domain.
DR InterPro; IPR024314; SUFU_C.
DR InterPro; IPR038489; SUFU_C_sf.
DR InterPro; IPR037181; SUFU_N.
DR InterPro; IPR007768; Suppressor_of_fused.
DR InterPro; IPR016591; Suppressor_of_fused_euk.
DR PANTHER; PTHR10928; SUPPRESSOR OF FUSED; 1.
DR PANTHER; PTHR10928:SF2; SUPPRESSOR OF FUSED HOMOLOG; 1.
DR Pfam; PF05076; SUFU; 1.
DR Pfam; PF12470; SUFU_C; 1.
DR PIRSF; PIRSF011844; Suppressor_of_fused_protein; 1.
DR SUPFAM; SSF103359; Suppressor of Fused, N-terminal domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 52..228
FT /note="Suppressor of fused-like"
FT /evidence="ECO:0000259|Pfam:PF05076"
FT DOMAIN 242..422
FT /note="Suppressor of fused C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12470"
FT REGION 314..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 46849 MW; A2B0642E6DCB8B15 CRC64;
KKHRPHGGAG AQALASLFPP GLHSIYGECR RLYPDQLNPL QVTAIVKYWL GGPDPLDYIS
MYRNLGNPAL GIPEHWHYVS FGLSDLYGDN RVHEFTGADG PSGFGFELTF RLKREAGESA
PPTWPAELMQ GLARYVFQSE NTFCSGDHVS WHSPLDNSES RIQHMLLTED PQLQPVPTPF
GLVSFLQIVG VCTEELQAAQ QWNGQGILEL LRTVPVAGGP WLITDMRRGE TIFEIDPHLQ
QERVDKGIET DGSNLSGVSA KCAWDDLSRP PEDEDDSRSI CIGTQPRRLS GKDTEQIREA
LKKGLEINSK SVLPPISSQR QNGMNHDWAP SRKDSLESES SAAIVPHELI RTRHLESVHL
KFNQESGTLI PLCLRGRLLH GRHFTYKSIT GDTAITFVST GVEGAFATEE HPYAAHGPWL
QV
//
