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Database: UniProt
Entry: H3ALX5_LATCH
LinkDB: H3ALX5_LATCH
Original site: H3ALX5_LATCH 
ID   H3ALX5_LATCH            Unreviewed;      1452 AA.
AC   H3ALX5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-JUN-2019, entry version 57.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000010646};
GN   Name=RAPGEF2 {ECO:0000313|Ensembl:ENSLACP00000010646};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010646, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000010646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000010646};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSLACP00000010646}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AFYH01113660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01113661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01113662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01113663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLACT00000010725; ENSLACP00000010646; ENSLACG00000009378.
DR   eggNOG; KOG3542; Eukaryota.
DR   eggNOG; ENOG410XS6B; LUCA.
DR   GeneTree; ENSGT00940000156418; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR030739; RapGEF2.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF217; PTHR23113:SF217; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168, ECO:0000256|SAAS:SAAS01081641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT   DOMAIN       63    163       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   DOMAIN      195    309       N-terminal Ras-GEF. {ECO:0000259|PROSITE:
FT                                PS50212}.
FT   DOMAIN      313    383       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      539    624       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN      649    876       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   REGION        1     29       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H3ALX5}.
FT   REGION      935    986       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H3ALX5}.
FT   REGION      995   1014       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H3ALX5}.
FT   REGION     1029   1083       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H3ALX5}.
FT   REGION     1177   1211       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H3ALX5}.
FT   REGION     1275   1358       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H3ALX5}.
FT   REGION     1401   1452       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H3ALX5}.
FT   COILED      156    176       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS      9     24       Acidic. {ECO:0000256|MobiDB-lite:H3ALX5}.
FT   COMPBIAS    954    986       Polar. {ECO:0000256|MobiDB-lite:H3ALX5}.
FT   COMPBIAS   1039   1083       Polar. {ECO:0000256|MobiDB-lite:H3ALX5}.
FT   COMPBIAS   1293   1307       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                H3ALX5}.
FT   COMPBIAS   1310   1339       Polar. {ECO:0000256|MobiDB-lite:H3ALX5}.
SQ   SEQUENCE   1452 AA;  162468 MW;  5CC9F693B59976BC CRC64;
     MDLSGLPETA VDSEDDDDEE DIERASDPLM SRDVVRDCLE KDPIDRTDDD IEQLLEFMHQ
     LPAFANMTMS VRKELCAVMV FAVVERAGTI VLNDGEELDS WSVILNGSVE VTYPDGRTEI
     LCMGNSFGVS PTMEKEYMKG VMKTKVDDCQ FVCIAQQDYC RILNQVEKNM QKVEEEGEIV
     MVKEHRELDR TGTRKGHIVI KGTPERLTMH LVEEHSVVDP TFIEDFLLTY RTFLSSPMEV
     GKKLLEWFND PSLRDKVTRV VLLWVNNHFN DFEGDTAMTR FLEEFENSLE REKMMGHLRL
     LNIACAAKAK RRLITLTKPS REAPLPFILL GGSEKGLGIF VDSVESGSKA AETGLKRGDR
     ILEVNGQNFE NVQLSKAMEI LKNNTHLSIT VKTNLFEFKQ LLTRLAEEKR NGAPHLPKIG
     DIKKASRYSI PDLAVDVEQV MGLEKVNKKS KANTVGGKNK LKKIFDKTRI SILPQKPYND
     IGIGQSQDDS IVGLRQSKHI PPTLPVSGNL SSSNPDLLQS HHRILDFNNS PAAGFYNLPD
     QVLRVFKADQ QSRYIMISKD TTAKEVVHQA LREFALTGPE NYSLCEVSVT PEGVIKQKRL
     PDQLSKLADK IQLSGRYYLK NNMETETLCS DEDAQELLKE SQISLLQLST IEVATQLSMR
     NFELFRNIEA TEYIDDLFKL KTKVGSSNLK KFEEVINQET FWVASEILKE LNQIKRMKII
     KHFIKIALHC RECKNFNSMF AIISGLNLAP VARLRSTWEK LNSKYEKLFQ DLQDLFDPSR
     NMAKYRNVLN SQNLQPPIIP LFPVIKKDLT FLHEGNDSKV EGLVNFEKLR MIAKEIRHVG
     RMASVNMDPA LMFRTRKKKW RSLGSLSQGS TNAALDVVQT GGHKKRVRRS SFLNAKKLYE
     DAQMARKVKQ YLANLVLEMD EDSLQVLSLV CEPSTNTLPK NAGDRRSGKC DTSPVTPRAG
     TQQPKTQQPQ PQQQQPQQQQ QKGNQALQVP PVSLYPSRKK VPVKDLPPFG TSSPQALRKI
     LSLSEEANFD RHKKQAEDTI SNASSQLSSP PTSPQTSPRK GGSQLRSHGS RHSDLTGSSS
     SLGSYTLAPS GTVDNFSDSG HSEISSRSSI VSNSSFDCVP MHDEKRQRHS VSIVEANLGV
     GRIDRRAVMD PDQYSFSSYS PVPENRSLYA GATVLSSPST EELTQDQGDR ASLDAADSGR
     GSWTSCSSGS HDNIQTIQHQ RSWETLAFGH THFDSAAEGA ALWASGNHMD QLMFSELANK
     CSRYSQAREN LDQAQSRGSW ASSPGYWGEE TEGDTGTIKR RGGKDVAAEA ETSSITSLTS
     EESKNIRPSH ITVSSSTAKG LIARKEGRYR EPPPTPPGYI GIPIADFPEV SSFQTRKPPD
     YNVALQRSRF VARPCEPLGA SATQQLHGHP AARTVNKPQW HRPNESDPRL ALYQSQGFSA
     EEEDEDEQVS AV
//
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