ID H3ALX7_LATCH Unreviewed; 178 AA.
AC H3ALX7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=BCL2 like 10 {ECO:0000313|Ensembl:ENSLACP00000010648.2};
GN Name=BCL2L10 {ECO:0000313|Ensembl:ENSLACP00000010648.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010648.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000010648.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
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DR EMBL; AFYH01203866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01203867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006009177.1; XM_006009115.1.
DR AlphaFoldDB; H3ALX7; -.
DR STRING; 7897.ENSLACP00000010648; -.
DR Ensembl; ENSLACT00000010727.2; ENSLACP00000010648.2; ENSLACG00000009379.2.
DR GeneID; 102360074; -.
DR KEGG; lcm:102360074; -.
DR CTD; 10017; -.
DR eggNOG; KOG4728; Eukaryota.
DR GeneTree; ENSGT01090000260003; -.
DR HOGENOM; CLU_1277283_0_0_1; -.
DR InParanoid; H3ALX7; -.
DR OMA; TDYLEYC; -.
DR OrthoDB; 4564633at2759; -.
DR TreeFam; TF334762; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000009379; Expressed in pelvic fin and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0090504; P:epiboly; IEA:Ensembl.
DR GO; GO:0007369; P:gastrulation; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR CDD; cd06845; Bcl-2_like; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR PANTHER; PTHR11256:SF47; BCL-2-LIKE PROTEIN 10; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR SMART; SM00337; BCL; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 159..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..138
FT /note="Bcl-2 Bcl-2 homology region 1-3"
FT /evidence="ECO:0000259|SMART:SM00337"
SQ SEQUENCE 178 AA; 19435 MW; 3689774BE44CDD85 CRC64;
MCDSLKEETR LLANDFIQFC LGSGRTAPNP AARVLRRVTA ELERQNQALF DSFQGNCGPE
AELGSVLKRV AEQLEAEGGL NWGRVVSLFA FAGCLAKGVQ RAQNEECAMG ACCGKLAEAL
VNYLAKERGD WLEENGGWDG FYKFFERSDH YQESTVRNAL MAAAGFGIAG LAFLLAVR
//
