ID   H3ANT7_LATCH            Unreviewed;       790 AA.
AC   H3ANT7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000011308.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000011308.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000011308.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00983}.
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DR   EMBL; AFYH01068281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01068282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01068283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01068284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01068285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3ANT7; -.
DR   STRING; 7897.ENSLACP00000011308; -.
DR   Ensembl; ENSLACT00000011394.1; ENSLACP00000011308.1; ENSLACG00000009948.1.
DR   eggNOG; KOG1998; Eukaryota.
DR   GeneTree; ENSGT00940000154974; -.
DR   InParanoid; H3ANT7; -.
DR   OMA; YLVRWPS; -.
DR   TreeFam; TF300423; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   Bgee; ENSLACG00000009948; Expressed in pectoral fin and 3 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd08694; C2_Dock-A; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR027007; C2_DOCK-type_domain.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR047026; DOCK1_C2.
DR   InterPro; IPR032376; DOCK_N.
DR   InterPro; IPR042455; DOCK_N_sub1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR   PANTHER; PTHR45653:SF1; DEDICATOR OF CYTOKINESIS PROTEIN 1; 1.
DR   Pfam; PF14429; DOCK-C2; 1.
DR   Pfam; PF16172; DOCK_N; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51650; C2_DOCK; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          5..66
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          421..605
FT                   /note="C2 DOCK-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51650"
FT   COILED          181..208
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   790 AA;  90876 MW;  5F45E59B8E86A3E9 CRC64;
     WYYIKKILSV ETIYNYDARV PEELSLQIGD TVHILEMHEG WYRGYTLRKK SRKGVFPVSY
     IHLKEATVEG KEQHETVIPN ELPLVQEVTT TLREWSTIWR QLYVQDNREM FHRVRNMIYD
     LIEWRSQILS GTLPQDELKE LKQKVTAKID YGNRILDLDL VVRDEDGNIM DPELTSTISL
     FRAHETASKQ VEERIQEEKS QKQNIDINRQ AKFAATPSFA LFVNLKNVVC KIGEDAEVLM
     SLYDPLESKF ISENYLVRWP SSGLPKDIDR LHNLRAVLTD LGSKDLKREK ISFVCQIVRV
     GRMELRDNNT KKLTSGLRRP FGVAVMDVTD IISGKVDDED KQHFIPFQPV AGENDFLQTV
     INKVIAAKEV NHKGQGLWVT MKLIPGDIHQ IRKDFPHLVD RSTAVARKMG FPEIIMPGDV
     RNDIYVTLVQ GDFDKGSKTT AKNVEVTMSV FDEDGKRLEN VIFPGAGDEA MSEYKSVIYY
     QVKQPRWFET VKVAIPIEDV NRSHLRFTFR HRSSQDSKDK SEKIFALAFV KLMRYDGTTL
     RDGEHDLIVY KVEAKKLDDV SLYLNLPSTK VELEEKGHVS TGKSMQNLGS CPISKDSFQI
     STLVCSTKLT QNVDLLGLLK WRSNTSLLQQ NLKQLMKVDG GEVVKFLQDT LDALFNIMME
     NSDSDTFDTL VFDALVFIIG LIADRKFQHF NPVLETYIRK HFSATLAYTK LTTVLKNYVD
     NAEKPGVTDQ LFKAMKALEY IFKFIVRSRI LFNQLYENKG EADFMDSLLL LFKSINDMMS
     SISDQTVMVK
//