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Database: UniProt
Entry: H3ANV2_LATCH
LinkDB: H3ANV2_LATCH
Original site: H3ANV2_LATCH 
ID   H3ANV2_LATCH            Unreviewed;       506 AA.
AC   H3ANV2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
GN   Name=ACVR1 {ECO:0000313|Ensembl:ENSLACP00000011323};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000011323, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000011323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000011323};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSLACP00000011323}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSLACP00000021853}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|SAAS:SAAS00595019}.
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DR   EMBL; AFYH01089153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01089154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01089155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01089156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01089157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01089158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01089159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01089160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01089161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01089162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005998008.1; XM_005997946.2.
DR   RefSeq; XP_005998009.1; XM_005997947.2.
DR   RefSeq; XP_014345107.1; XM_014489621.1.
DR   RefSeq; XP_014345108.1; XM_014489622.1.
DR   STRING; 7897.ENSLACP00000011323; -.
DR   Ensembl; ENSLACT00000011409; ENSLACP00000011323; ENSLACG00000009962.
DR   Ensembl; ENSLACT00000025709; ENSLACP00000021853; ENSLACG00000009962.
DR   GeneID; 102345137; -.
DR   KEGG; lcm:102345137; -.
DR   CTD; 90; -.
DR   eggNOG; KOG2052; Eukaryota.
DR   eggNOG; ENOG410XQT0; LUCA.
DR   GeneTree; ENSGT00940000160160; -.
DR   KO; K04675; -.
DR   OMA; LCNMNIT; -.
DR   OrthoDB; 776697at2759; -.
DR   TreeFam; TF314724; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   SMART; SM00467; GS; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00138218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00138186};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    506       Receptor protein serine/threonine kinase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014093676.
FT   TRANSMEM    121    143       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      175    204       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      205    499       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   506 AA;  56639 MW;  EB3D70967F00C2FA CRC64;
     MLDGVMILPV LMILAFPPSS IEEEESKLNT ILYECVCEGM SCENGDRCSG QQCFASLSIN
     DGTPVYQKGC FQVYEQGKMN CKTPPSSDQA VECCQGHLCN QNITTQLPVG QHGDSYSVTT
     LTIVIIAPVV MLIILSLLAV MTFRKIHHHQ MERLNARDAE YGTIDGLISS NVGDSTLADL
     LDHSCTSGSG SGLPFLVQRT VARQITLMEC VGKGRYGEVW RGLWQGENVA VKIFSSRDER
     SWCRETEIYN TVLLRHENIL GFIASDMTSR NSSTQLWLIS HYHEMGSLYD YLQLTTLDSV
     GCLRIVLSIA CGLAHLHVEI YGTQGKPAIA HRDLKSKNIL VKKNGQCCIA DLGLAVMHCQ
     STNQLDVGNN PRVGTKRYMS PEVLDEIIQV DCFDSYKRVD IWAFGLVLWE VARRTVSNGI
     VEDYKPPFHD VVPNDPSFED MRKVVCVDQQ RPIIPNRWFS DPTLTSLAKL MKECWYQNPS
     ARLTALRIKK TLTKIDNSLD KLKPEC
//
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