ID H3APA3_LATCH Unreviewed; 2400 AA.
AC H3APA3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Dynein axonemal heavy chain 14 {ECO:0008006|Google:ProtNLM};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000011474.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000011474.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01130909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01130910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01130911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01130912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01130913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01130914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01130915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01130916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01130917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01130918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000011474; -.
DR Ensembl; ENSLACT00000011562.1; ENSLACP00000011474.1; ENSLACG00000010093.1.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000165101; -.
DR HOGENOM; CLU_000038_3_1_1; -.
DR InParanoid; H3APA3; -.
DR OMA; KHSYESC; -.
DR TreeFam; TF335573; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000010093; Expressed in chordate pharynx and 1 other cell type or tissue.
DR GO; GO:0005929; C:cilium; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22878:SF67; DYNEIN AXONEMAL HEAVY CHAIN 14; 1.
DR PANTHER; PTHR22878; UNCHARACTERIZED; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 471..556
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 625..882
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 903..1191
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 1320..1540
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 1788..1904
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 1940..2079
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 2086..2396
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 1117..1165
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2400 AA; 274401 MW; 87C1E790CD5350F4 CRC64;
WIVLDGPVDM IWVENLNTAL DETKTLCFAN GERISMPQGI RFVFEVDSLS QASPATVSRC
AMIYMMHMQD PVDLGWEPYV KTWLSHLPEE LPKNGVSYLQ ILFEKSIEEG LNFICNFDSI
KCIWIAVCTF FPIKGSKLFL QNTFFSFPIF VYREKKKWFL QKFPDKLITI LGKLYVFAFT
WAVGGVLKRD VSEEDSMHAP KNKDEPLVHV TAEFDNLVHD LFDGEPPVAN ANIIPHRNSK
DSKLKKKNTC YCALKFHHIK STTTLLSRFL GLSSLDLLIV KLICGDTDRQ TKKNLIKNTV
KKNITTPHTC THSIQFSTQT SAATTKSHIL CNLIRRSGEN FGPPRNKKVI VFIDDLNMPA
PEPYGAKPPL ELIRQFLELN GFYEHNKNVW KNIDGISLVA TCSVSDGGRN EISPRLLTHF
CMIVLPEPSI LSLQSIFQNI LFLKYNTEVQ LGRHFENRDF PSDVQKCGEG LVAATLAVYY
KMYNNMLPTP AKSHYIFSLH DLSKVIRGLL QADEYVITTV ETTVQLFAHE ATRVFHDRLI
SACDRNVFHQ FLSDELQIHF AICLPFQKLM QEPIVFGDFL PTDSPDGNRY YSPIADQKYL
TSILEQYQME HQLTKGLINH TEVPFVYFKE TVDHITRAAR IFRQPDGHMM LVGLNGTGKL
SCATLACYLS GCSLYRLPIT QSYCHADFQE DLKKIFWQTG LRRKETVLFI TEADIVKESV
LEDLNYILNI GEVPHLFDKE EIDRITVALK AAAIDSNIPD NKHAIYAFFL QRVRRKLHIV
LATSPAGPTF RQRCRETPSF INCCTIDWYD EWPKEALLEV ANSSVIKEDI GENDEELKEN
IAQVCVEIHE SACMAAARCL EEYRRHYYIS PSSFLVFINL FCSTLQTKKK EILNDRYNCF
RDRYQNGLCR LSEGMELVTI MQEELIAIGP KIEQNSEDIE ALMEKLESDT KIMEKIHAIV
KEEEEVMNQE TQVVEDYANQ ATNELNAVLP ALYQSIANLN ALRKEDISEV RVYSNPPDLV
LTVMYAVCIL LQHTPNWLTA KQLLGDPGFL KMLVNLDKDS IAEKVFMRLK RYTKDPDFNP
EKVGLVSVAC RPMCQWVLAL EKYHEVHKAV QPKKDKVMEA NEALVEIQEN LKQKRKNLFR
IEEHLQNLQQ KYADSIAERK ALAEKKIVTT QRLQRATVLI SVLDDEQIIH CSIIEEGGSV
YYKFSKIKEV NELCLRPKKL NLILAVLPGH SLIALCYCKL WLLITIARWK EVTDELNHKV
QNITGDVLIS AALIVYSDVL TANYRRMMVK EWIGFCNSYN VPVSQDYNLV KVMVDKNQLR
SWHSAGLPLD QYSMENAVLV KMGQLWPLLI DPQKQIYKWI CQMEGDMLQK VHATDPNYLR
IVQSAIELGK PVLLQNVSER LDPSLMPVLA KNIYRKDGQD FIRIGNNEIK YDHNFRLYMT
TQIANPRFLP AVCITITLIN FTVTIESLQD QLLSSVVRHE YPELEEQHDQ LLESLTADLL
TLQELEKKSL TLLQRTGNDI LDDNDLIDTL QRSKVTSKEI KQRVQDSEAI EREIKAAREK
YHPIANRGAV LYFTVVELLQ LNYMYQFSLD WFLQLYLSSI SPRTQQLRNS LRAHFIRAIA
ALTENVHKVV SNALFSDHQL CFSFMICTNI MRNNVTESNT LDTMGFLPKS VNELDRNDSP
VPWLTDTIWK QCHYISTHLK SFSHLCESLI SNPQQWNYFW RNDEALESPR TYFPWEKLSS
FQRLILISVL KPECLTSAVR EFVVEKLGSR FVRSGGSNLK GVYSSSNANI PFIFILSPGA
DPSIQFLRFA TEMRGNTQHV HMMSLGKGQG PKAEELINKA QILKGRWVFL QNCHLAASFM
PQLESIVEVL CRTSSVIDLN FRLWLSSKPD PSFPVSILQS GIKVAVEPIH GLKGMLLQTF
GSDGEVTEKI YDNEKAGPLW KKLLFNLCFF SAVIHGRKKY GSLGWNFPYE FTSSDLEVSI
QILEMLVNDQ SEIPWSALRC LTGEVVYGGH VTDYWDQRCL LHILESFYNP TALQQGCAFS
SDKEYWSLSE EANLEECGTY IRTLPDADSP EIFGMHLNAE KTFLENQAQA FIDTIITMQP
QLSTACLTTS GGKSQDEMVL EMASDILRRL PEAVEKKYGL KPGYDSLVHS ATPMFLYQEI
ERFNHLLSVI HSSLHSLSLA VKGTIILTDE LEQVYNSFLN MRVCELWQKH SYESCKMLGS
WIDDLIQRID FFGTWAEQNS PVKIFWLSGF FFPQGFLTAV LQNYARQKGV SVDSLTFTYR
VLSTTTDKDG FHSNEGILVF GLYLDGARWD SITQTLGESQ LGQRFSCVPM IHFLPQNAPD
QNSSVLTCYK CPLYQTSKRA GTLASTGLST NFVTAVHLPT SVSPSHWVIR GVALLCQLDD
//
