ID H3AQE2_LATCH Unreviewed; 855 AA.
AC H3AQE2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Patched domain containing 3 (gene/pseudogene) {ECO:0000313|Ensembl:ENSLACP00000011863.1};
GN Name=PTCHD3 {ECO:0000313|Ensembl:ENSLACP00000011863.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000011863.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000011863.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; AFYH01183505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AQE2; -.
DR STRING; 7897.ENSLACP00000011863; -.
DR Ensembl; ENSLACT00000011954.1; ENSLACP00000011863.1; ENSLACG00000010440.1.
DR eggNOG; KOG1934; Eukaryota.
DR GeneTree; ENSGT00940000158727; -.
DR HOGENOM; CLU_002359_2_2_1; -.
DR InParanoid; H3AQE2; -.
DR OMA; MWHITFF; -.
DR TreeFam; TF331806; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796:SF60; PATCHED DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..805
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 263..420
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 855 AA; 97017 MW; ACD350CCC2E27EB4 CRC64;
MAGCQTDCVQ KPLSEAFQKL GHLVGRNPWG FLLIPLLLAG ILGTGFYFYP QDKVNEIEEL
FVPVNAPVKA EKELLQRLFP SNDSVYFSSQ RLSTEGIYVS LIAVSRSDNI LTEAAFGDIL
KLDRQVKDLS LRKDNTSYDF SNLCVKSNLS CYNNLILNEI NYNASQIESK KFTYPVYKND
FMGLVLGGVK VNSNSVIEQA KAFRLDYYLR DDEEHRNISI MWLHKFVEEF PSDLMQLDID
TIEVSYYTSI SRQQEFEVSH QTVIPLFSMA YSFSVLFSVL PYLRFDCVKN KVWVVMFGVI
SAGLSLLASF GLLLYCGVPF AITIANSPFL ILGIGVDDVF VIISCWQQTK VKSKVEERLA
ETYAEAAVPI TITTLTDIFA FYSGIMTPYQ SVKSFCIYTG TAVFFCFLYN ITFFGAILAI
NGKREEENKH WLTCMKVDNV SRPGHSKAYN VCCAGGIYDE ATGLDKQQPI NVFFKRHYGP
FLLQISTKVF VVLLYTIYLT ISIYGCLQIK EGMDYHNMAD DKSYIMKYYD FEGAYFSEYG
PRIMVAVTDK VEYWDQTVQE NIEKCMKRFE NYTYVDKSFT ESWLRVYKNA SNRLLTSPYD
KAQFMSNLPH LFQPFPMFEQ DISIANNTIL ASRFFIQTAN IASVFDEKSS EKKLREIGKE
CSVPLLVYHP AFLYDDQHVQ IVQTTIESIV MSIAVMLVIS LLLIPNAICS LCATFAVVSI
LAGVAGFMAF WAVNLDSMSM VNLVSCIGFS VDFSVHISYA FSSNRNSNVN EKIIDSLHCL
GYPFIQRAVA TILGVAVLSA AECYIFRCFF KIMFLVMFFG SVHGLIFIPV FLTFLADCCK
AHDKTVKVKM NEKKV
//
