ID H3ARV1_LATCH Unreviewed; 223 AA.
AC H3ARV1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Ectodysplasin A {ECO:0000313|Ensembl:ENSLACP00000012372.1};
GN Name=EDA {ECO:0000313|Ensembl:ENSLACP00000012372.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000012372.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000012372.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; AFYH01080766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01080767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3ARV1; -.
DR STRING; 7897.ENSLACP00000012372; -.
DR Ensembl; ENSLACT00000012465.1; ENSLACP00000012372.1; ENSLACG00000010893.1.
DR eggNOG; ENOG502QUAV; Eukaryota.
DR GeneTree; ENSGT00730000111220; -.
DR HOGENOM; CLU_090525_0_0_1; -.
DR InParanoid; H3ARV1; -.
DR OMA; SRIAMNP; -.
DR TreeFam; TF332099; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 82..217
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..38
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..62
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 223 AA; 23399 MW; 43F838BED0178D84 CRC64;
QVFNRFSGKK QGPPGAPGPQ GPPGPPGPQG PPGIPGIPGI PGTNVIGTPG PPGPPGPQGP
PGAQGPSGTV DKPGGRDVQP AVVHLQGQGS AIQVKNDLSG GVLNDWSRIA MNPRVFKLHT
RTGELEVLVD GTYFIYSQVE VYYINFTDFA SYEIVVDEKP FLQCTRSIET GKTSFNTCYT
AGVSLLKARQ KIAVKMVHAD ISINMSKHTT FFGAIRLGEA PSS
//
