ID H3ASY1_LATCH Unreviewed; 547 AA.
AC H3ASY1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN Name=KPNA5 {ECO:0000313|Ensembl:ENSLACP00000012752.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000012752.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000012752.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; AFYH01168982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01168983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01168984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01168985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01168986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01168987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01168988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01168989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3ASY1; -.
DR STRING; 7897.ENSLACP00000012752; -.
DR Ensembl; ENSLACT00000012846.1; ENSLACP00000012752.1; ENSLACG00000011231.1.
DR eggNOG; KOG0166; Eukaryota.
DR GeneTree; ENSGT01050000244950; -.
DR InParanoid; H3ASY1; -.
DR OMA; NWSTISV; -.
DR TreeFam; TF354205; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000011231; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF10; IMPORTIN SUBUNIT ALPHA-6; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 3..66
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 176..218
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 218..246
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 547 AA; 61441 MW; FC53A0977A95918C CRC64;
KYIIFFLHTM ASPVKDNYRM KSYKNKALNP QEMRRRREEE GIQLRKQKRE EQLFKRRNVS
LPLNDEAMLE NPIQDPDVSS TVPVTGEGSI TADMVQMIFS DDSDQQLAAT QKFRKLLSKE
PNPPIDEVIQ TKGIVHRFVE FLKRNENCIL QFEAAWALTN IASGTFLHTK VVIETGAVPV
FIELLNSDHE DVQEQAVWAL GNIAGDNAEC RDFVLNCGIL PPLLQLLTKS TRLTTTRNAV
WALSNLCRGK NPPPDFSKKV CPCLNVLSRL LFSSDPDVLA DACWALSYLS DGPNDKIQAV
IDSGVCRRLV ELLMHNDYKV VSPALRAVGN IVTGDDIQTQ VILNCSALPC LLHLLSSLKE
SIRKEACWTV SNITAGNRAQ IQAVIDANIF PVLIEILQKA EFRTRKEATW AITNATSGGT
PEQIRYLVAL GSIKPLCDLL TVMDSKIVQV ALNGLENILR LGEQESKQNG TGINPYCALI
EEAYGLDKIE FLQSHENQEI YQKAFDLIEH YFGVEEEDTN IAPQVDESQQ QFVFQQQQEA
PMEGFHL
//
