ID   H3AT24_LATCH            Unreviewed;       709 AA.
AC   H3AT24;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE            EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000012795.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000012795.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC       HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR   EMBL; AFYH01166638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3AT24; -.
DR   STRING; 7897.ENSLACP00000012795; -.
DR   Ensembl; ENSLACT00000012889.1; ENSLACP00000012795.1; ENSLACG00000011272.1.
DR   eggNOG; KOG0017; Eukaryota.
DR   GeneTree; ENSGT01100000263560; -.
DR   HOGENOM; CLU_000384_38_0_1; -.
DR   InParanoid; H3AT24; -.
DR   OMA; THWVHIS; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33064:SF29; LRRGT00076; 1.
DR   PANTHER; PTHR33064; POL PROTEIN; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT   DOMAIN          5..186
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          277..402
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
FT   DOMAIN          543..701
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
SQ   SEQUENCE   709 AA;  79349 MW;  039234644D375669 CRC64;
     ISALLEQKVL RTCISTCNSP VWLVRKPNGS WRLTVDYRRL NSVTPPMAPI VADITHLATK
     LQPSHSFSSV LDISNGFWSL PLHPLCQYKF AFTFQETQHT WTCLPQGFHN SPALFHSVMK
     DALASFPYQQ NLVQYVDDHL LASPDLKSHI IHLKALLTAL TKAGLKINPD KAQLCRQQVS
     FLGITITPSG RAIDQHKLSV ILSLPLPTDV TSLRSFLGMC NFMHLFVFNF SVVCKPLYTL
     LRADNSFTWT EDHTEAITTL KQALTSAPVL SAPNYLIPFH LFIANSFSSL AAVLAQSDCE
     LAALIQALSD HQDQAVTIYS DSSWTVMSAA SYLLQWHKNG FLSSDGKPLK HQHMLKMLFV
     LLKTRQDSQL DTIMVKIKAY TYGSAVATYN NTVDGLAKQA AVSGHCWVVP DIDLSTIQTT
     TPVAAVAVTL PDDLKALQDM DPTIHNMVTM DPHVVCIEGI FYRTDPTTGC PVYIPPVELR
     SLLITNIHAR GHLAAESTYR TLAQSFWWPR MWKDVEKYCS YCIPCAMLSP PARKIQGPLP
     IRTSDGPWSS IFIDYIDGMP RSPGGHTHIL VVVRAFTKWV EAFPITKTSA KATAKVLLDL
     FCRWGIPASV DSDRGPHFAN EVMKQALQAL GVKHHLHIPY RPQASGQVER VNRTLKASIK
     RICLEQRATW VESLPWLLMA LRSRVDKRTG YSPFQVMMGR VMWLPENLL
//