ID H3AT42_LATCH Unreviewed; 389 AA.
AC H3AT42;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Ribonucleoside-diphosphate reductase subunit M2 {ECO:0000256|ARBA:ARBA00040401};
DE EC=1.17.4.1 {ECO:0000256|ARBA:ARBA00012274};
DE AltName: Full=Ribonucleotide reductase small chain {ECO:0000256|ARBA:ARBA00042512};
GN Name=RRM2 {ECO:0000313|Ensembl:ENSLACP00000012813.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000012813.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000012813.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase small
CC chain family. {ECO:0000256|ARBA:ARBA00009303}.
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DR EMBL; AFYH01095559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01095560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01095561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005998739.1; XM_005998677.2.
DR AlphaFoldDB; H3AT42; -.
DR STRING; 7897.ENSLACP00000012813; -.
DR Ensembl; ENSLACT00000012907.2; ENSLACP00000012813.2; ENSLACG00000011284.2.
DR GeneID; 102361010; -.
DR KEGG; lcm:102361010; -.
DR CTD; 6241; -.
DR eggNOG; KOG1567; Eukaryota.
DR GeneTree; ENSGT00390000013305; -.
DR HOGENOM; CLU_035339_2_1_1; -.
DR InParanoid; H3AT42; -.
DR OMA; KVGEYQR; -.
DR OrthoDB; 5487627at2759; -.
DR TreeFam; TF300465; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000011284; Expressed in pelvic fin and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:InterPro.
DR CDD; cd01049; RNRR2; 1.
DR Gene3D; 1.10.620.20; Ribonucleotide Reductase, subunit A; 1.
DR InterPro; IPR009078; Ferritin-like_SF.
DR InterPro; IPR012348; RNR-like.
DR InterPro; IPR033909; RNR_small.
DR InterPro; IPR030475; RNR_small_AS.
DR InterPro; IPR000358; RNR_small_fam.
DR PANTHER; PTHR23409; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN; 1.
DR PANTHER; PTHR23409:SF20; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2; 1.
DR Pfam; PF00268; Ribonuc_red_sm; 1.
DR SUPFAM; SSF47240; Ferritin-like; 1.
DR PROSITE; PS00368; RIBORED_SMALL; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
SQ SEQUENCE 389 AA; 44821 MW; 993E3C9B56AE14FE CRC64;
MLSSRSPLST KNENVMVAKM NSVSLTESQK ENTPPSLNST RILASRTARK IFQDGETDSV
KSKVNDLQDE PLLRENPRRF VIFPIQYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWDSLK
AEEKYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI
DTYIKSPEER EYLFNAVETL PCVKKKADWA LHWIGDCQSS YGERVVAFAA VEGIFFSGSF
ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL INKPSEQKVR EILIDAVKIE
QEFLTDALPV NLIGMNCTLM KQYIEFVADR LMLELGFGKI FRAENPFDFM ENISLEGKTN
FFEKRVGEYQ RMGVMAKATE NTFTLDADF
//
