ID H3ATB4_LATCH Unreviewed; 956 AA.
AC H3ATB4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Fucose kinase {ECO:0000313|Ensembl:ENSLACP00000012885.1};
GN Name=FCSK {ECO:0000313|Ensembl:ENSLACP00000012885.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000012885.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000012885.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GHMP kinase family.
CC {ECO:0000256|ARBA:ARBA00038121}.
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DR EMBL; AFYH01132514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01132515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01132516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01132517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01132518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01132519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01132520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01132521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01132522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01132523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3ATB4; -.
DR STRING; 7897.ENSLACP00000012885; -.
DR Ensembl; ENSLACT00000012979.1; ENSLACP00000012885.1; ENSLACG00000011345.1.
DR eggNOG; KOG4644; Eukaryota.
DR GeneTree; ENSGT00390000002251; -.
DR HOGENOM; CLU_006983_0_0_1; -.
DR InParanoid; H3ATB4; -.
DR OMA; QKMFSYC; -.
DR TreeFam; TF314554; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProt.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:UniProt.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 3.30.230.120; -; 1.
DR InterPro; IPR012887; Fucokinase.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR036554; GHMP_kinase_C_sf.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR32463; L-FUCOSE KINASE; 1.
DR PANTHER; PTHR32463:SF0; L-FUCOSE KINASE; 1.
DR Pfam; PF07959; Fucokinase; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..370
FT /note="L-fucokinase"
FT /evidence="ECO:0000259|Pfam:PF07959"
FT DOMAIN 707..767
FT /note="GHMP kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00288"
FT DOMAIN 851..927
FT /note="GHMP kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08544"
SQ SEQUENCE 956 AA; 105075 MW; A839076B3ECAB159 CRC64;
QLAIGCPPGV WVCSTDMILT ISSTPEISWD AFRGVRVVSV PGDVAYARDH GVYLFNQQGF
VCNIIYQGSD ERIRQCAQED GRVPLVSGIV FFSSEAAEHL LATHVVPPLD ACTYMGLDSG
ARPIQTLLYL NGLACSCENA PATDFIFTSF PIFLRQYDPE TANLAKKTKP IIWKVERRCD
ATIFSAYVPD GCYSYMTMSA RDHIQTLTVR TKDISGFMFH KVVHSHITHP QLLEEGCSVV
NSLLEREVLV RSQSVIQHCH LQGSCQIGPG CFLSGVDMTS AAALQNCQLS DAIIQGHNIR
LRDMRVKVFT AFGHHDDLQV SPATEASTFL NLKWTEFFKR TGISYSDIWK QGARSEVENL
LNAQLFPVFH ASEPVGIEDV LWFLGLEAKG KSQSCLQKWL SSWRMSLKEI LACLDQEAEL
EARRQLFFTR AQHRVRDVLL TRKDNGLLPL FRAAVNEGYE LQIVTTLDQV ATETMDPGVA
ARALACIADV LGCAAKGEGG LRSGPAANQS WSQAFQLLES GNVAQGVLKL SEERAKWLGR
PNLLVRAARH YEGAEQILIR QAVMSACRFI TTERTESPPL NQWVVAECPA RIDISGGWSD
TPPITYEHGG AVVNIAILVD KRKPIGARAR RIAEPRLVLG STSGVREGEA ETVIVCETLD
DVRDYCQPHA PGALLKAAFI CTKIICYPSH KSLQAQLLER FGGGFELHTW SNLPHGSGLG
TSSILAGAIM ASLSRAAGLV YDPDSLIHAV LHLEQILTTG GGWQDQVGGL VPGIKIGKSK
AQLPLKVEVE QLPIPESFIQ TLNEHLLLVY TGKTRLARNL LQDVLRNWYA RLPSIVQNAD
ALVKNAEECA RAFTEGDLPR IGQCLERYWQ QKKCMAPGCE PQAVRRMMRA LQPHVYGQSL
AGAGGGGFLY LLTRKPRQKE AIQEILANTQ SLGSISVHAV EVDMTGISVR LSSTGQ
//
