ID H3AU37_LATCH Unreviewed; 245 AA.
AC H3AU37;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Fibroblast growth factor {ECO:0000256|RuleBase:RU049442};
DE Short=FGF {ECO:0000256|RuleBase:RU049442};
GN Name=FGF13A {ECO:0000313|Ensembl:ENSLACP00000013158.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000013158.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000013158.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004135}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, growth cone
CC {ECO:0000256|ARBA:ARBA00004624}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000256|ARBA:ARBA00007936, ECO:0000256|RuleBase:RU049442}.
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DR EMBL; AFYH01024653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01024654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01024655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01024656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01024657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01024658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01024659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01024660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01024661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01024662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005990391.1; XM_005990329.2.
DR AlphaFoldDB; H3AU37; -.
DR Ensembl; ENSLACT00000013254.1; ENSLACP00000013158.1; ENSLACG00000011588.1.
DR GeneID; 102346439; -.
DR CTD; 492758; -.
DR GeneTree; ENSGT00940000163347; -.
DR HOGENOM; CLU_081609_2_0_1; -.
DR OMA; GTCEKNK; -.
DR OrthoDB; 5348469at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000011588; Expressed in chordate pharynx and 4 other cell types or tissues.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00058; FGF; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR PANTHER; PTHR11486:SF77; FIBROBLAST GROWTH FACTOR 13; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR PRINTS; PR00262; IL1HBGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 27685 MW; 0E5007DE4D3DDD9B CRC64;
MAAAIASSLI RQKRQARERE KSNACKCVNS PSKNKGTCEK NKLNVFSRVK IFSTKKKRRR
RPEPQLKGIV TKLYSRQGYH LQLQADGTID GTKEEDSAYT LFNLIPVGLR VVAIQGVQTK
LYLAMNSEGY LYTSEHFTPE CKFKESVFEN YYVTYSSMIY RQQQSGRGWY LGLNKEGEIM
KGNHVKKNKP AAHFLPKPIK VVMYREPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKTVS
QNEST
//
