ID H3AU85_LATCH Unreviewed; 1169 AA.
AC H3AU85;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Stonin 1 {ECO:0000313|Ensembl:ENSLACP00000013206.1};
GN Name=STON1 {ECO:0000313|Ensembl:ENSLACP00000013206.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000013206.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000013206.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Stoned B family.
CC {ECO:0000256|ARBA:ARBA00005579}.
CC -!- SIMILARITY: Belongs to the TFIIA subunit 1 family.
CC {ECO:0000256|ARBA:ARBA00010059}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01100593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01100594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01100595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01100596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01100597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01100598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01100599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01100600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01100601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01100602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AU85; -.
DR STRING; 7897.ENSLACP00000013206; -.
DR Ensembl; ENSLACT00000013302.1; ENSLACP00000013206.1; ENSLACG00000011629.2.
DR eggNOG; KOG2652; Eukaryota.
DR eggNOG; KOG2677; Eukaryota.
DR GeneTree; ENSGT00940000158817; -.
DR HOGENOM; CLU_008237_0_0_1; -.
DR InParanoid; H3AU85; -.
DR TreeFam; TF318623; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005672; C:transcription factor TFIIA complex; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd07976; TFIIA_alpha_beta_like; 2.
DR Gene3D; 1.10.287.100; -; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR Gene3D; 2.30.18.10; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR012320; SHD_dom.
DR InterPro; IPR004855; TFIIA_asu/bsu.
DR InterPro; IPR009088; TFIIA_b-brl.
DR PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR PANTHER; PTHR10529:SF339; STONIN-1; 1.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR Pfam; PF03153; TFIIA; 1.
DR SMART; SM01371; TFIIA; 1.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR SUPFAM; SSF47396; Transcription factor IIA (TFIIA), alpha-helical domain; 1.
DR SUPFAM; SSF50784; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR PROSITE; PS51072; MHD; 1.
DR PROSITE; PS51070; SHD; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 252..385
FT /note="SHD"
FT /evidence="ECO:0000259|PROSITE:PS51070"
FT DOMAIN 389..696
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..77
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1118
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1169 AA; 131260 MW; BA4B253663E11526 CRC64;
MCSTNQANWV TFDDDFPSQS PPKSSQLIIP RPNGLKLSLP GLHESSSGSS SSSSTPLSSP
LPDFRVSPGP PSNTPLCTPI RDYPVSPCTP KAGFHSLYGI SGKSTPNTPL ASPGSDFFIN
VPSTNKTPLT SSIIDCPLSH PAGKQETQMP VSGSPSRNNI FSNLEIPSPT NKFKPFQNES
GYSNPFWRQK HVSESRSDQK KTINSSFTYI CKKLEGLQAD NLEKLRNSSS YSEANSCSFV
SQSLFRSRNQ DGWPFMLRIP EKKNMMSSRQ WGPIYLKVVP RGILQMYYEK GLEKPFKELQ
LHPYCRLSEQ KLESFGDLGK IHTIKIENVS YIEKRRYHPK AEVVHEAELE QLLKLGTTDY
NDFSDFIITV EEELMRLPLI SKQKKNYEEQ EMILEIIDNF WGKITKDEGK LIESAVVTHI
YCLCFINGST ECFLTLNDLQ LQRKDDSYFE EGIKDHLIEI GEYSFHKCVK EHEFENSRII
KFIPPDACRV ELLRFKSLCN MTDIPFSIKA LVMVQGAYIE LQAFLNMAPT RTDSLNLKSL
KYCENVMIRF PVPAGWIKVF RTVNLLRQKS LKAKMNRSAC LGSINEMESE PVVQVTIGAA
KYENAYKAIV WKIDRLPDKN SASDHPHCFS CKLELGSDQE IPFDWYPFIT VEFEMPGTYA
SGTNVKSVGT ESDIQPQKHI LQKACYHYQP KLYRSIIEDV IDGVQELFVE EGIDDQVLKE
LKQRWESKVI HSKAMEGFFR DHSHSPQFVL QLPQNYHPAL QKSADSIVIP ASKSVQSYTT
ADLSSSGTNT TFTLPAGISY PVQIPAGVTL QTASGHLYKV NVPVMVTQAP GGSRMFQQPI
PQMFQQLSHS AGQSAAIQSS TVPVQRALQQ QAESLHQPIS VLIQQPVVLN QVFIQQNERS
KNHPNESVET PAISQQSEIQ QESNVITSQS SGLHSVLQEP VATSPYPVVQ QEESDGIEEV
ILLDDEGEKS ITNEQTCPKQ NASELLKMQL LTPERKIPKN NFSESSHTVA TLCSLQGTSE
TKASNRTLNE DSHNDDQDII QVDGIYDTSS DEEAVNEQDV NENEFLGIID AEDLKALEEG
ISSSEDSASS NSEDEECQVE IVEEDPLNSG DDVSEQDVPD LFDTDNVIVC QYDKIHRSKN
KWKFYLKDGV MCFGGKDYVF SKAVGEAEW
//
