ID H3AU86_LATCH Unreviewed; 364 AA.
AC H3AU86;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=CCN family member 1 {ECO:0000256|ARBA:ARBA00039941};
DE AltName: Full=Cellular communication network factor 1 {ECO:0000256|ARBA:ARBA00042351};
DE AltName: Full=Protein CYR61 {ECO:0000256|ARBA:ARBA00042204};
GN Name=LOC102363594 {ECO:0000313|Ensembl:ENSLACP00000013207.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000013207.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000013207.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR EMBL; AFYH01128314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01128315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006002304.1; XM_006002242.1.
DR AlphaFoldDB; H3AU86; -.
DR Ensembl; ENSLACT00000013303.1; ENSLACP00000013207.1; ENSLACG00000011630.1.
DR GeneID; 102363594; -.
DR KEGG; lcm:102363594; -.
DR GeneTree; ENSGT00940000155151; -.
DR HOGENOM; CLU_063247_1_0_1; -.
DR OrthoDB; 2970572at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000011630; Expressed in pelvic fin and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348:SF18; CCN FAMILY MEMBER 1; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..364
FT /note="CCN family member 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003580217"
FT DOMAIN 18..90
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 94..160
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 269..343
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 364 AA; 40849 MW; F0EBBD40B4CF0363 CRC64;
MEQTLLIVIL SIACFSLVKS GCPTECRCPA SPPQCTPGVS LVLDGCGCCK VCARQLNDDC
SKTEPCDHHK GLECNFGADP WANRGICRAK LEGRTCEYNG KIYQNGENFQ PNCKHQCTCI
DGAVGCVPLC PMELALASPD CPKPRLVKIP SQCCERFVCD KQVKKHKGVT FDYVPYPGFH
SNELIHLGKH RSMKNLAAWR PLFEERSVQK KCILQTTEWS QCSKTCGMGV STRVTNDNPQ
CKLVKETRLC NIRPCGQSTF TKLKKGRKCT RTRKSKEPIR FSYAGCKSIK KYQPNYCGTC
VDGRCCAPLK TRTASVRFRC DDGDTFEKNI MMIQSCKCSL DCSQLNEVVQ PYYSLYNDIH
KFLE
//
