ID H3AWK4_LATCH Unreviewed; 476 AA.
AC H3AWK4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=N-lysine methyltransferase SETD6 {ECO:0000256|ARBA:ARBA00016973, ECO:0000256|PIRNR:PIRNR011771};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR011771};
GN Name=SETD6 {ECO:0000313|Ensembl:ENSLACP00000014025.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014025.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000014025.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Protein-lysine N-methyltransferase.
CC {ECO:0000256|PIRNR:PIRNR011771}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR011771}.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC {ECO:0000256|PIRNR:PIRNR011771}.
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DR EMBL; AFYH01152823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01152824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AWK4; -.
DR Ensembl; ENSLACT00000014124.1; ENSLACP00000014025.1; ENSLACG00000012344.2.
DR GeneTree; ENSGT00940000153577; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000012344; Expressed in pelvic fin and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19178; SET_SETD6; 1.
DR Gene3D; 3.90.1420.10; Rubisco LSMT, substrate-binding domain; 1.
DR Gene3D; 3.90.1410.10; set domain protein methyltransferase, domain 1; 1.
DR InterPro; IPR011383; N-lys_methylase_SETD6.
DR InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044430; SETD6_SET.
DR PANTHER; PTHR13271:SF34; N-LYSINE METHYLTRANSFERASE SETD6; 1.
DR PANTHER; PTHR13271; UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE; 1.
DR Pfam; PF09273; Rubis-subs-bind; 1.
DR Pfam; PF00856; SET; 1.
DR PIRSF; PIRSF011771; RMS1_SET; 1.
DR SUPFAM; SSF81822; RuBisCo LSMT C-terminal, substrate-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR011771};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR011771};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PIRNR:PIRNR011771};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR011771}.
FT DOMAIN 62..288
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
SQ SEQUENCE 476 AA; 54435 MW; 8072D11631B3420A CRC64;
MASIAKRAKC SLQNEFCYPC PPQVMAILPL PSSDSNAARN PADEVLSAFL DWCEKVDVKL
SSKVYISKEG TVSGYGMLAR EDIDEGEVLF SVPRKVLLNH ETTSIHTLLE KENLSLQSPS
GWVPLLMSLL YEYTNEKSHW KPYFSLWMDF KGLEHPMFWS EQERAKLLQG TGIPEAVATD
LINIQKEYNT IVLPFMKSHP TLFDPKKHTL ELYKKLVAFV MAYSFQDPPE DEDDEDDKDP
NPPMMVPMAD ILNHVANHNA NLEFTPECLK MVSVRKISQG EEVFNTYGQM ANWQLLHMYG
FVEPYPGNIN EAADIQMSTM HKAAVLGTKS EAERKFVTEK WDLLCKLEMV GEEGAFVIGL
TEVLTEEELF TTLKVLTMSA EEFEDYKENE DWEEVEDDEE VSSMTDEIHK LKLPWKQLLH
SSAELTLASY KTDLKADEHL ITNPEAYSKL SQREQTSLQV RYGQKKILHQ LLDLTK
//
