ID H3AWP2_LATCH Unreviewed; 782 AA.
AC H3AWP2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Zinc finger FYVE-type containing 1 {ECO:0000313|Ensembl:ENSLACP00000014063.1};
GN Name=ZFYVE1 {ECO:0000313|Ensembl:ENSLACP00000014063.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014063.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000014063.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01112233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01112234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01112235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01112236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006000562.1; XM_006000500.2.
DR AlphaFoldDB; H3AWP2; -.
DR STRING; 7897.ENSLACP00000014063; -.
DR Ensembl; ENSLACT00000014162.1; ENSLACP00000014063.1; ENSLACG00000012379.1.
DR GeneID; 102348921; -.
DR KEGG; lcm:102348921; -.
DR CTD; 53349; -.
DR eggNOG; KOG1818; Eukaryota.
DR GeneTree; ENSGT00390000016097; -.
DR HOGENOM; CLU_020922_0_0_1; -.
DR InParanoid; H3AWP2; -.
DR OMA; RYTHQYD; -.
DR OrthoDB; 277036at2759; -.
DR TreeFam; TF323237; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000012379; Expressed in chordate pharynx and 4 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd19819; Bbox1_ZFYVE1_rpt1; 1.
DR CDD; cd19820; Bbox1_ZFYVE1_rpt2; 1.
DR CDD; cd15734; FYVE_ZFYV1; 1.
DR CDD; cd01851; GBP; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR042427; ZFYV1.
DR InterPro; IPR047856; ZFYVE1_first_BBox1.
DR InterPro; IPR047855; ZFYVE1_second_BBox1.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46624; AGAP002036-PA; 1.
DR PANTHER; PTHR46624:SF3; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01363; FYVE; 2.
DR SMART; SM00064; FYVE; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50178; ZF_FYVE; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 40..69
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 602..663
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 720..780
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
SQ SEQUENCE 782 AA; 87550 MW; 06BB5CAF4113175F CRC64;
MSSQALALDK GLSTVPMCQE SYACSGSDEA IFECDECASL QCQSCEKELH KQERLKNHER
IRIGPGHIPY CDPCKGNNGN LVHSSAATAR QRAAVRCLGC KINLCIECQK RTHSVVNKRK
HPITVYRVSK IQDQQEEGMD EETRKRKMSE KVRSFLLVDE NEDIQVINEE EFILRLGCKP
DENLKVVSIF GNTGDGKSHT INHTFFYGRE VFKTSPAQES CTVGVWAAYD PVHRVVVLDT
EGLLGATMNL SQRTRLLLKV LAISDIIIYR THADRLHDDL FKFLGDASEA YLKHFTKELK
ATTARCGLDV PLSTLGPAVI LFHETIHTKL LGSDKPSEQP EKLLQERFRK LGRFPEAFSS
IQYKGTRTYN PPTDFSGLLR AVEQQLENNT TRSPRHAGVI YKALKALSDR FSGEISDDQT
AQSSFFPDEY FTCSCVCLSC GAGCRNSMNH MKEGVAHVAN SRCKYSSQYD NRVYTCKACY
EGGKEVIVVP KTSASTDSPW TGLVKYAWSG YVLECPNCGV IYRSRQYWYG NLDPVDTVVR
TEIEHIWQGM DGFLKDNNNA AQRLLDGVNF MAQSVSELSV KPTKVVTSWI TDQIAPAYWT
PNSRITRCHN CGHSFKDNDS KHHCRACGEG FCDSCSSKTR PVPERGWGPT PVRVCDRCYD
QTGEPTELVG DVTEEDEGGT LIARKVGEAV QNTLGAVVTA MDIPLGLVKD AARPTYWIPD
HEILQCNNCQ KEFTMKVSKH HCRACGQGFC DECSQERRAV PSRGWDHPVR VCMNCSKKPG
DL
//
